COASY

GENE INFORMATION

? »

Gene name

COASY (HGNC Symbol)

Synonyms

CoASY, DPCK, NBP, PPAT

Description

CoA synthase (HGNC Symbol)

Entrez gene summary

Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]

Chromosome

17

Cytoband

q21.2

Chromosome location (bp)

42561467 - 42566277

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000068120 (version 78.38)

Entrez gene

80347

UniProt

Q13057 (UniProt - Evidence at protein level)

neXtProt

NX_Q13057

Antibodypedia

COASY antibodies
 

PROTEIN VIEW

? »
 
 
 
COASY-001
 
COASY-002
 
COASY-003
 
COASY-007
 
COASY-008
 
COASY-009
 
COASY-010
 
COASY-011
 
COASY-012
 
COASY-013
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COASY-001 ENSP00000393564
ENST00000421097
Q13057
Show all »
Show » Show » 564 62.3 Yes 0
COASY-002 ENSP00000464814
ENST00000590958
Q13057
Show all »
Show » Show » 593 65.3 No 0
COASY-003 ENSP00000377406
ENST00000393818
Q13057
Show all »
Show » Show » 564 62.3 Yes 0
COASY-007 ENSP00000467174
ENST00000585811
K7EP09
Show all »
Show » 91 9.9 Yes 0
COASY-008 ENSP00000467519
ENST00000585909
K7EPT0
Show all »
Show » 98 10.4 No 0
COASY-009 ENSP00000466838
ENST00000586771
K7EN91
Show all »
Show » Show » 219 23.7 Yes 0
COASY-010 ENSP00000467687
ENST00000591779
K7EQ60
Show all »
Show » Show » 116 12.9 No 0
COASY-011 ENSP00000467322
ENST00000587157
K7EPC2
Show all »
Show » 96 10.5 No 0
COASY-012 ENSP00000468583
ENST00000587214
K7ES73
Show all »
Show » Show » 147 16.1 Yes 0
COASY-013 ENSP00000468755
ENST00000587858
K7ESK6
Show all »
Show » 128 13.8 No 0