SPI1

GENERAL INFORMATION

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Gene name

SPI1

Gene description

Spi-1 proto-oncogene

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

Intracellular,Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

High nuclear expression in a subset of leukocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA044653 , CAB004079
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SPI1 (HGNC Symbol)

Synonyms

OF, PU.1, SFPI1, SPI-1, SPI-A

Description

Spi-1 proto-oncogene (HGNC Symbol)

Entrez gene summary

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

47354860 - 47378576

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000066336 (version 78.38)

Entrez gene

6688

UniProt

P17947 (UniProt - Evidence at protein level)

neXtProt

NX_P17947

Antibodypedia

SPI1 antibodies


PROTEIN BROWSER

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ENST00000227163
 
ENST00000378538
 
ENST00000533030
 
ENST00000533968
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPI1-001 ENSP00000367799
ENST00000378538
P17947
Show all »
Show » Show » 270 31.1 No 0
SPI1-002 ENSP00000438846
ENST00000533968
F5H3K6
Show all »
Show » 245 27.4 No 1
SPI1-003 ENSP00000443865
ENST00000533030
F5GZ94
Show all »
Show » 35 3.7 No 0
SPI1-004 ENSP00000227163
ENST00000227163
P17947
Show all »
Show » Show » 271 31.2 No 0