KARS

GENE INFORMATION

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Gene name

KARS (HGNC Symbol)

Synonyms

DFNB89, KARS1, KARS2

Description

Lysyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q23.1

Chromosome location (bp)

75627474 - 75648643

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000065427 (version 78.38)

Entrez gene

3735

UniProt

Q15046 (UniProt - Evidence at protein level)

neXtProt

NX_Q15046

Antibodypedia

KARS antibodies
 

PROTEIN VIEW

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KARS-001
 
KARS-002
 
KARS-007
 
KARS-009
 
KARS-011
 
KARS-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KARS-001 ENSP00000303043
ENST00000302445
Q15046
Show all »
Show » Show » 597 68 No 0
KARS-002 ENSP00000325448
ENST00000319410
Q15046
Show all »
Show » Show » 625 71.5 No 0
KARS-007 ENSP00000462057
ENST00000568682
J3KRL2
Show all »
Show » Show » 102 12.1 No 0
KARS-009 ENSP00000454512
ENST00000568378
H3BMR9
Show all »
Show » 67 7.7 No 0
KARS-011 ENSP00000455488
ENST00000566772
H3BPV7
Show all »
Show » Show » 104 12.2 No 0
KARS-012 ENSP00000458028
ENST00000570215
H3BVA8
Show all »
Show » Show » 256 29.1 No 0