RFXANK

GENE INFORMATION

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Gene name

RFXANK (HGNC Symbol)

Synonyms

ANKRA1, BLS, F14150_1, MGC138628, RFX-B

Description

Regulatory factor X-associated ankyrin-containing protein (HGNC Symbol)

Entrez gene summary

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

19192229 - 19201869

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000064490 (version 78.38)

Entrez gene

8625

UniProt

O14593 (UniProt - Evidence at protein level)

neXtProt

NX_O14593

Antibodypedia

RFXANK antibodies
 

PROTEIN VIEW

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RFXANK-001
 
RFXANK-002
 
RFXANK-003
 
RFXANK-004
 
RFXANK-005
 
RFXANK-008
 
RFXANK-012
 
RFXANK-014
 
RFXANK-015
 
RFXANK-017
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RFXANK-001 ENSP00000305071
ENST00000303088
O14593
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Show » Show » 260 28.1 No 0
RFXANK-002 ENSP00000409138
ENST00000456252
O14593
Show all »
Show » Show » 238 25.7 No 0
RFXANK-003 ENSP00000384572
ENST00000407360
O14593
Show all »
Show » Show » 260 28.1 No 0
RFXANK-004 ENSP00000376138
ENST00000392324
A0A024R7P0
Show all »
Show » Show » 237 25.6 No 0
RFXANK-005 ENSP00000393159
ENST00000421262
F5H7D2
Show all »
Show » Show » 83 8.7 No 0
RFXANK-008 ENSP00000440325
ENST00000540981
F5GY33
Show all »
Show » Show » 188 20.2 No 0
RFXANK-012 ENSP00000444280
ENST00000535017
H0YGQ6
Show all »
Show » Show » 182 19.6 No 0
RFXANK-014 ENSP00000440321
ENST00000536253
H0YFU5
Show all »
Show » 41 4.6 No 0
RFXANK-015 ENSP00000441042
ENST00000544923
H0YFZ0
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Show » 47 5.3 No 0
RFXANK-017 ENSP00000466913
ENST00000593273
K7ENE6
Show all »
Show » Show » 145 15.7 No 0