RASGRF1

GENE INFORMATION

? »

Gene name

RASGRF1 (HGNC Symbol)

Synonyms

CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187

Description

Ras protein-specific guanine nucleotide-releasing factor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

Chromosome

15

Cytoband

q25.1

Chromosome location (bp)

78959947 - 79090773

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000058335 (version 78.38)

Entrez gene

5923

UniProt

Q13972 (UniProt - Evidence at protein level)

neXtProt

NX_Q13972

Antibodypedia

RASGRF1 antibodies
 

PROTEIN VIEW

? »
 
 
 
RASGRF1-001
 
RASGRF1-002
 
RASGRF1-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RASGRF1-001 ENSP00000405963
ENST00000419573
Q13972
Show all »
Show » Show » 1273 145.2 No 0
RASGRF1-002 ENSP00000452781
ENST00000558480
Q13972
Show all »
Show » Show » 1257 143.2 No 0
RASGRF1-003 ENSP00000378228
ENST00000394745
Q13972
Show all »
Show » Show » 489 55.5 No 0