PTPRN

GENE INFORMATION

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Gene name

PTPRN (HGNC Symbol)

Synonyms

IA-2

Description

Protein tyrosine phosphatase, receptor type, N (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

219289623 - 219309648

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000054356 (version 78.38)

Entrez gene

5798

UniProt

Q16849 (UniProt - Evidence at protein level)

neXtProt

NX_Q16849

Antibodypedia

PTPRN antibodies
 

PROTEIN VIEW

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PTPRN-001
 
PTPRN-003
 
PTPRN-008
 
PTPRN-009
 
PTPRN-011
 
PTPRN-012
 
PTPRN-013
 
PTPRN-020
 
PTPRN-021
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRN-001 ENSP00000295718
ENST00000295718
Q16849
Show all »
Show » Show » 979 105.8 Yes 1
PTPRN-003 ENSP00000386638
ENST00000409251
Q16849
Show all »
Show » Show » 950 102.8 Yes 1
PTPRN-008 ENSP00000395379
ENST00000446182
C9JK57
Show all »
Show » 125 13.6 No 0
PTPRN-009 ENSP00000397105
ENST00000451506
C9J392
Show all »
Show » 67 7.5 No 0
PTPRN-011 ENSP00000408036
ENST00000440552
C9JR27
Show all »
Show » 166 18.1 No 0
PTPRN-012 ENSP00000388429
ENST00000412847
C9JK57
Show all »
Show » 125 13.6 No 0
PTPRN-013 ENSP00000396464
ENST00000442029
C9JCQ0
Show all »
Show » 86 9.2 No 0
PTPRN-020 ENSP00000396842
ENST00000443981
Show » Show » 137 15.6 No 0
PTPRN-021 ENSP00000392598
ENST00000423636
Q16849
Show all »
Show » Show » 889 96.3 No 1