RAD51 - Gene info - The Human Protein Atlas

Gene name

RAD51 (HGNC Symbol)

Synonyms

BRCC5, HsRad51, HsT16930, RAD51A, RECA

Description

RAD51 recombinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Chromosome

Cytoband

q15.1

Chromosome location (bp)

40694774 - 40732339

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000051180 (version 78.38)

Entrez gene

5888

UniProt

Q06609 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAD51-001

ENSP00000267868
ENST00000267868

Q06609
Show all » « Hide

Q06609 [Direct mapping]
DNA repair protein RAD51 homolog 1
E9PNT5 [Target identity:50%; Query identity:100%]
DNA repair protein RAD51 homolog 1 {ECO:0000313|Ensembl:ENSP00000432759}
Q9NZG9 [Target identity:22%; Query identity:100%]
DNA repair protein RAD51 homolog 1 {ECO:0000313|Ensembl:ENSP00000431897}; RAD51 {ECO:0000313|EMBL:AAF61901.1}

Show » « Hide

Predicted intracellular proteins
Cytoskeleton related proteins
Cancer-related genes
Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000730 [DNA recombinase assembly]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005856 [cytoskeleton]
GO:0006200 [ATP catabolic process]
GO:0006259 [DNA metabolic process]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007126 [meiotic nuclear division]
GO:0007131 [reciprocal meiotic recombination]
GO:0008022 [protein C-terminus binding]
GO:0008094 [DNA-dependent ATPase activity]
GO:0009432 [SOS response]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0042802 [identical protein binding]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051106 [positive regulation of DNA ligation]
GO:0051260 [protein homooligomerization]
GO:0070182 [DNA polymerase binding]
GO:0071479 [cellular response to ionizing radiation]
GO:0072757 [cellular response to camptothecin]

339

RAD51-002

ENSP00000406602
ENST00000423169

Q06609
Show all » « Hide

Q06609 [Direct mapping]
DNA repair protein RAD51 homolog 1
E9PNT5 [Target identity:61%; Query identity:100%]
DNA repair protein RAD51 homolog 1 {ECO:0000313|Ensembl:ENSP00000432759}
Q9NZG9 [Target identity:26%; Query identity:100%]
DNA repair protein RAD51 homolog 1 {ECO:0000313|Ensembl:ENSP00000431897}; RAD51 {ECO:0000313|EMBL:AAF61901.1}

Show » « Hide

280

RAD51-003

ENSP00000454176
ENST00000557850

Q06609
Show all » « Hide

Q06609 [Direct mapping]
DNA repair protein RAD51 homolog 1
Q9NZG9 [Target identity:30%; Query identity:100%]
DNA repair protein RAD51 homolog 1 {ECO:0000313|Ensembl:ENSP00000431897}; RAD51 {ECO:0000313|EMBL:AAF61901.1}

Show » « Hide

GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000730 [DNA recombinase assembly]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005856 [cytoskeleton]
GO:0006200 [ATP catabolic process]
GO:0006259 [DNA metabolic process]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007126 [meiotic nuclear division]
GO:0007131 [reciprocal meiotic recombination]
GO:0008022 [protein C-terminus binding]
GO:0008094 [DNA-dependent ATPase activity]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0042802 [identical protein binding]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051106 [positive regulation of DNA ligation]
GO:0051260 [protein homooligomerization]
GO:0070182 [DNA polymerase binding]
GO:0071479 [cellular response to ionizing radiation]
GO:0072757 [cellular response to camptothecin]

242

26.4

RAD51-006

ENSP00000431897
ENST00000526763

Q9NZG9
Show all » « Hide

Q9NZG9 [Target identity:100%; Query identity:100%]
DNA repair protein RAD51 homolog 1 {ECO:0000313|Ensembl:ENSP00000431897}; RAD51 {ECO:0000313|EMBL:AAF61901.1}

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000166 [nucleotide binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]

8.2

RAD51-007

ENSP00000432759
ENST00000527860

E9PNT5
Show all » « Hide

E9PNT5 [Target identity:100%; Query identity:100%]
DNA repair protein RAD51 homolog 1 {ECO:0000313|Ensembl:ENSP00000432759}
Q9NZG9 [Target identity:43%; Query identity:100%]
DNA repair protein RAD51 homolog 1 {ECO:0000313|Ensembl:ENSP00000431897}; RAD51 {ECO:0000313|EMBL:AAF61901.1}

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000166 [nucleotide binding]
GO:0003677 [DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006200 [ATP catabolic process]
GO:0006259 [DNA metabolic process]
GO:0006281 [DNA repair]
GO:0008094 [DNA-dependent ATPase activity]
GO:0009432 [SOS response]

172

18.8

RAD51-008

ENSP00000433924
ENST00000532743

Q06609
Show all » « Hide

Q06609 [Direct mapping]
DNA repair protein RAD51 homolog 1
Q9NZG9 [Target identity:22%; Query identity:100%]
DNA repair protein RAD51 homolog 1 {ECO:0000313|Ensembl:ENSP00000431897}; RAD51 {ECO:0000313|EMBL:AAF61901.1}

Show » « Hide

340

36.8

RAD51-009

ENSP00000372088
ENST00000382643

Q06609
Show all » « Hide

Show » « Hide

GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000730 [DNA recombinase assembly]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0000800 [lateral element]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005856 [cytoskeleton]
GO:0006200 [ATP catabolic process]
GO:0006259 [DNA metabolic process]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007126 [meiotic nuclear division]
GO:0007131 [reciprocal meiotic recombination]
GO:0008022 [protein C-terminus binding]
GO:0008094 [DNA-dependent ATPase activity]
GO:0009432 [SOS response]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0042802 [identical protein binding]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051106 [positive regulation of DNA ligation]
GO:0051260 [protein homooligomerization]
GO:0070182 [DNA polymerase binding]
GO:0071479 [cellular response to ionizing radiation]
GO:0072757 [cellular response to camptothecin]

340

36.8

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.