FOXP3

GENERAL INFORMATION

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Gene name

FOXP3

Gene description

Forkhead box P3

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (appendix)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in a subset of immune cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB026301
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (appendix)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

FOXP3 (HGNC Symbol)

Synonyms

AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID

Description

Forkhead box P3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p11.23

Chromosome location (bp)

49250436 - 49264826

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000049768 (version 78.38)

Entrez gene

50943

UniProt

Q9BZS1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZS1

Antibodypedia

FOXP3 antibodies


PROTEIN BROWSER

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ENST00000376197
 
ENST00000376199
 
ENST00000376207
 
ENST00000455775
 
ENST00000518685
 
ENST00000557224
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOXP3-001 ENSP00000365380
ENST00000376207
Q9BZS1
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Show » Show » 431 47.2 No 0
FOXP3-002 ENSP00000365369
ENST00000376197
Q9BZS1
Show all »
Show » Show » 441 48.4 No 0
FOXP3-003 ENSP00000428952
ENST00000518685
Q9BZS1
Show all »
Show » Show » 396 43.4 No 0
FOXP3-004 ENSP00000451208
ENST00000557224
Q9BZS1
Show all »
Show » Show » 456 49.8 No 0
FOXP3-201 ENSP00000365372
ENST00000376199
Q9BZS1
Show all »
Show » Show » 396 43.4 No 0
FOXP3-202 ENSP00000396415
ENST00000455775
B7ZLG1
Show all »
Show » Show » 454 49.7 No 0