Tissue expression of PSMA4 - Summary - The Human Protein Atlas

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PSMA4

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	PSMA4
Gene description	Proteasome (prosome, macropain) subunit, alpha type, 4
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic and nuclear expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 3 antibodies. HPA055466 , HPA060613 , CAB004973
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	PSMA4 (HGNC Symbol)
Synonyms	HC9, HsT17706
Description	Proteasome (prosome, macropain) subunit, alpha type, 4 (HGNC Symbol)
Entrez gene summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	78540405 - 78552419
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000041357 (version 78.38)
Entrez gene	5685
UniProt	P25789 (UniProt - Evidence at protein level)
neXtProt	NX_P25789
Antibodypedia	PSMA4 antibodies

PROTEIN BROWSER

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ENST00000044462		ENST00000413382		ENST00000558094		ENST00000558281		ENST00000558341		ENST00000559082		ENST00000559146		ENST00000559154		ENST00000559365		ENST00000559437		ENST00000559948		ENST00000560217		ENST00000560737

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
PSMA4-001	ENSP00000044462 ENST00000044462	P25789 Show all » « Hide P25789 [Direct mapping] Proteasome subunit alpha type-4 H0YL69 [Target identity:90%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} Q7Z474 [Target identity:90%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203} H0YMZ1 [Target identity:84%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMA1 [Target identity:80%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:69%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Threonine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0000932 [cytoplasmic mRNA processing body] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular vesicular exosome]	261	29.5	No
PSMA4-004	ENSP00000402118 ENST00000413382	P25789 Show all » « Hide P25789 [Direct mapping] Proteasome subunit alpha type-4	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Threonine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0000932 [cytoplasmic mRNA processing body] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004298 [threonine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular vesicular exosome]	190	21.4	No
PSMA4-006	ENSP00000453887 ENST00000559082	P25789 Show all » « Hide P25789 [Direct mapping] Proteasome subunit alpha type-4 H0YL69 [Target identity:90%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} Q7Z474 [Target identity:90%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203} H0YMZ1 [Target identity:84%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMA1 [Target identity:80%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:69%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Threonine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0000932 [cytoplasmic mRNA processing body] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0070062 [extracellular vesicular exosome]	261	29.5	No
PSMA4-009	ENSP00000453829 ENST00000560217	H0YN18 Show all » « Hide H0YN18 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type-4 {ECO:0000313\|Ensembl:ENSP00000453829}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004298 [threonine-type endopeptidase activity] GO:0005839 [proteasome core complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	230	26.3	No
PSMA4-012	ENSP00000453080 ENST00000560737	H0YL69 Show all » « Hide H0YL69 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMZ1 [Target identity:93%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMA1 [Target identity:88%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:76%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	236	26.4	No
PSMA4-014	ENSP00000452936 ENST00000559948	H0YKT8 Show all » « Hide H0YKT8 [Target identity:99%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005839 [proteasome core complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	182	20.1	No
PSMA4-015	ENSP00000453802 ENST00000559365	H0YMZ1 Show all » « Hide H0YMZ1 [Target identity:99%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YMA1 [Target identity:94%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:81%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	221	24.6	No
PSMA4-016	ENSP00000453523 ENST00000559437	H0YMA1 Show all » « Hide H0YMA1 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551} H0YKT8 [Target identity:86%; Query identity:100%] Proteasome subunit beta type {ECO:0000256\|RuleBase:RU004203}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	209	23.3	No
PSMA4-017	ENSP00000453323 ENST00000558341	H0YLS6 Show all » « Hide H0YLS6 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	125	13.9	No
PSMA4-018	ENSP00000453621 ENST00000559146	H0YMI6 Show all » « Hide H0YMI6 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	183	20.5	No
PSMA4-019	ENSP00000453145 ENST00000558281	H0YLC2 Show all » « Hide H0YLC2 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type {ECO:0000256\|RuleBase:RU000551}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004175 [endopeptidase activity] GO:0004298 [threonine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005839 [proteasome core complex] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0019773 [proteasome core complex, alpha-subunit complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	174	19.7	No
PSMA4-020	ENSP00000452917 ENST00000559154	H0YKS0 Show all » « Hide H0YKS0 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type-4 {ECO:0000313\|Ensembl:ENSP00000452917}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004298 [threonine-type endopeptidase activity] GO:0005839 [proteasome core complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	122	13.6	No
PSMA4-021	ENSP00000453758 ENST00000558094	H0YMV3 Show all » « Hide H0YMV3 [Target identity:100%; Query identity:100%] Proteasome subunit alpha type-4 {ECO:0000313\|Ensembl:ENSP00000453758}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004298 [threonine-type endopeptidase activity] GO:0005839 [proteasome core complex] GO:0051603 [proteolysis involved in cellular protein catabolic process]	86	9.9	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx