MSR1

GENERAL INFORMATION

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Gene name

MSR1

Gene description

Macrophage scavenger receptor 1

Protein class

Cancer-related genes
CD markers
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

Selective expression in macrophages.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA000272 , CAB032491
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

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Gene name

MSR1 (HGNC Symbol)

Synonyms

CD204, SCARA1

Description

Macrophage scavenger receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p22

Chromosome location (bp)

16107878 - 16567490

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000038945 (version 78.38)

Entrez gene

4481

UniProt

P21757 (UniProt - Evidence at protein level)

neXtProt

NX_P21757

Antibodypedia

MSR1 antibodies


PROTEIN BROWSER

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ENST00000262101
 
ENST00000350896
 
ENST00000355282
 
ENST00000381998
 
ENST00000445506
 
ENST00000518026
 
ENST00000518960
 
ENST00000522672
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MSR1-001 ENSP00000262101
ENST00000262101
P21757
Show all »
Show » Show » 451 49.8 No 1
MSR1-002 ENSP00000347430
ENST00000355282
P21757
Show all »
Show » Show » 388 42.9 No 1
MSR1-003 ENSP00000371428
ENST00000381998
P21757
Show all »
Show » Show » 358 39.6 No 1
MSR1-004 ENSP00000405453
ENST00000445506
B4DDJ5
Show all »
Show » Show » 469 51.7 No 1
MSR1-006 ENSP00000430536
ENST00000522672
H0YBY2
Show all »
Show » Show » 149 15.9 No 0
MSR1-007 ENSP00000429498
ENST00000518026
E5RI91
Show all »
Show » 58 6.5 No 0
MSR1-008 ENSP00000427905
ENST00000518960
E5RFW8
Show all »
Show » Show » 64 7.3 No 0
MSR1-201 ENSP00000262100
ENST00000350896
P21757
Show all »
Show » Show » 388 42.9 No 1