TLL1

GENE INFORMATION

? »

Gene name

TLL1

Synonyms

Description

Tolloid-like 1 (HGNC Symbol)

Entrez gene summary

This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

4

Cytoband

q32.3

Chromosome location (bp)

165873258 - 166103895

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000038295 (version 78.38)

Entrez gene

7092

UniProt

O43897 (UniProt - Evidence at protein level)

neXtProt

NX_O43897

Antibodypedia

TLL1 antibodies
 

PROTEIN VIEW

? »
 
 
 
TLL1-001
 
TLL1-003
 
TLL1-004
 
TLL1-005
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TLL1-001 ENSP00000061240
ENST00000061240
O43897
Show all »
Show » Show » 1013 114.7 No 0
TLL1-003 ENSP00000422937
ENST00000513213
O43897
Show all »
Show » Show » 392 44.2 No 0
TLL1-004 ENSP00000426082
ENST00000507499
E9PD25
Show all »
Show » Show » 1036 117.3 No 0
TLL1-005 ENSP00000423748
ENST00000506144
D6RCE0
Show all »
Show » Show » 111 12.8 No 0