USP2

GENE INFORMATION

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Gene name

USP2 (HGNC Symbol)

Synonyms

UBP41

Description

Ubiquitin specific peptidase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

11

Cytoband

q23.3

Chromosome location (bp)

119355215 - 119381726

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000036672 (version 78.38)

Entrez gene

9099

UniProt

O75604 (UniProt - Evidence at protein level)

neXtProt

NX_O75604

Antibodypedia

USP2 antibodies
 

PROTEIN VIEW

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USP2-001
 
USP2-002
 
USP2-003
 
USP2-004
 
USP2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USP2-001 ENSP00000260187
ENST00000260187
O75604
Show all »
Show » Show » 605 68.1 No 0
USP2-002 ENSP00000407842
ENST00000455332
O75604
Show all »
Show » Show » 362 41.7 No 0
USP2-003 ENSP00000436952
ENST00000525735
O75604
Show all »
Show » Show » 396 45.2 No 0
USP2-004 ENSP00000431857
ENST00000527843
E9PJ34
Show all »
Show » 137 14.7 No 0
USP2-005 ENSP00000433977
ENST00000531070
E9PSH6
Show all »
Show » 168 18.3 No 0