CYP46A1

GENE INFORMATION

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Gene name

CYP46A1 (HGNC Symbol)

Synonyms

CYP46

Description

Cytochrome P450, family 46, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q32.2

Chromosome location (bp)

99684304 - 99727301

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000036530 (version 78.38)

Entrez gene

10858

UniProt

Q9Y6A2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6A2

Antibodypedia

CYP46A1 antibodies
 

PROTEIN VIEW

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CYP46A1-001
 
CYP46A1-003
 
CYP46A1-004
 
CYP46A1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP46A1-001 ENSP00000261835
ENST00000261835
Q9Y6A2
Show all »
Show » Show » 500 56.8 Yes 0
CYP46A1-003 ENSP00000369577
ENST00000380228
Show » Show » 487 55.1 No 0
CYP46A1-004 ENSP00000450553
ENST00000554176
Q9Y6A2
Show all »
Show » Show » 337 38.3 No 0
CYP46A1-006 ENSP00000451602
ENST00000556313
H0YJI0
Show all »
Show » Show » 164 18.7 No 0