MAP2K3 - Gene info - The Human Protein Atlas

Gene name

MAP2K3 (HGNC Symbol)

Synonyms

MAPKK3, MEK3, MKK3, PRKMK3

Description

Mitogen-activated protein kinase kinase 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p11.2

Chromosome location (bp)

21284672 - 21315240

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000034152 (version 78.38)

Entrez gene

5606

UniProt

P46734 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K3-001

ENSP00000345083
ENST00000342679

P46734
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P46734 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 3
Q6FI23 [Target identity:100%; Query identity:100%]
MAP2K3 protein {ECO:0000313|EMBL:CAG38752.1}; Mitogen-activated protein kinase kinase 3 isoform B {ECO:0000313|EMBL:BAG70040.1}; cDNA, FLJ96569, Homo sapiens mitogen-activated protein kinase kinase 3 (MAP2K3),transcript variant B, mRNA {ECO:0000313|EMBL:BAG37889.1}
E9PRZ0 [Target identity:46%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 3 {ECO:0000313|Ensembl:ENSP00000434068}
D3DXI2 [Target identity:34%; Query identity:100%]
HCG28371, isoform CRA_a {ECO:0000313|EMBL:EAX02602.1}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0045087 [innate immune response]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051403 [stress-activated MAPK cascade]
GO:0060048 [cardiac muscle contraction]

347

39.3

MAP2K3-011

ENSP00000431203
ENST00000529517

E9PMA8
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E9PMA8 [Target identity:100%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 3 {ECO:0000313|Ensembl:ENSP00000431203}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

101

10.9

MAP2K3-013

ENSP00000319139
ENST00000316920

P46734
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P46734 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 3
E9PRZ0 [Target identity:50%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 3 {ECO:0000313|Ensembl:ENSP00000434068}
D3DXI2 [Target identity:37%; Query identity:100%]
HCG28371, isoform CRA_a {ECO:0000313|EMBL:EAX02602.1}

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GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051403 [stress-activated MAPK cascade]

318

36.2

MAP2K3-014

ENSP00000462178
ENST00000527123

J3KRV4
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J3KRV4 [Target identity:100%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 3 {ECO:0000313|Ensembl:ENSP00000462178}

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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008152 [metabolic process]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

136

MAP2K3-016

ENSP00000434068
ENST00000526076

E9PRZ0
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E9PRZ0 [Target identity:100%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 3 {ECO:0000313|Ensembl:ENSP00000434068}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

160

18.2

MAP2K3-201

ENSP00000355081
ENST00000361818

P46734
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318

36.2

MAP2K3-202

ENSP00000478619
ENST00000613338

P46734
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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318

36.2

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.