GAB2

GENE INFORMATION

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Gene name

GAB2 (HGNC Symbol)

Synonyms

KIAA0571

Description

GRB2-associated binding protein 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Chromosome

11

Cytoband

q14.1

Chromosome location (bp)

78215297 - 78418348

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000033327 (version 78.38)

Entrez gene

9846

UniProt

Q9UQC2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UQC2

Antibodypedia

GAB2 antibodies
 

PROTEIN VIEW

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GAB2-001
 
GAB2-002
 
GAB2-003
 
GAB2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GAB2-001 ENSP00000354952
ENST00000361507
Q9UQC2
Show all »
Show » Show » 676 74.5 No 0
GAB2-002 ENSP00000343959
ENST00000340149
Q9UQC2
Show all »
Show » Show » 638 70 No 0
GAB2-003 ENSP00000433762
ENST00000528886
E9PJE2
Show all »
Show » 131 14.7 No 0
GAB2-005 ENSP00000431868
ENST00000530915
E9PJ26
Show all »
Show » 102 11.7 No 0