Tissue expression of CD44 - Summary - The Human Protein Atlas

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CD44

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	CD44
Gene description	CD44 molecule (Indian blood group)
Protein class	Blood group antigen proteins Cancer-related genes CD markers FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	25
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous staining in most epithelial and lymphatic tissues.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 3 antibodies. HPA005785 , CAB000112 , CAB000316
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CD44 (HGNC Symbol)
Synonyms	CD44R, CSPG8, HCELL, IN, MC56, MDU2, MDU3, MIC4, Pgp1
Description	CD44 molecule (Indian blood group) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p13
Chromosome location (bp)	35138870 - 35232402
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000026508 (version 78.38)
Entrez gene	960
UniProt	P16070 (UniProt - Evidence at protein level)
neXtProt	NX_P16070
Antibodypedia	CD44 antibodies

PROTEIN BROWSER

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ENST00000263398		ENST00000278385		ENST00000278386		ENST00000279452		ENST00000352818		ENST00000415148		ENST00000428726		ENST00000433892		ENST00000434472		ENST00000442151		ENST00000524922		ENST00000525211		ENST00000525469		ENST00000525685		ENST00000525688		ENST00000526000		ENST00000526025		ENST00000526553		ENST00000526669		ENST00000527889		ENST00000528455		ENST00000528672		ENST00000531110		ENST00000531873		ENST00000533222

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CD44-001	ENSP00000398632 ENST00000428726	P16070 Show all » « Hide P16070 [Direct mapping] CD44 antigen E9PKC6 [Target identity:10%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000435377} C1PHC3 [Target identity:6%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1} B4XHE2 [Target identity:5%; Query identity:100%] CD44 {ECO:0000313\|EMBL:ABW75083.1} C0STK4 [Target identity:5%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1} C1PHC4 [Target identity:5%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C1PHE6 [Target identity:3%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57879.1}	Show » « Hide CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0002246 [wound healing involved in inflammatory response] GO:0004415 [hyalurononglucosaminidase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0005975 [carbohydrate metabolic process] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010628 [positive regulation of gene expression] GO:0016055 [Wnt signaling pathway] GO:0016323 [basolateral plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0019221 [cytokine-mediated signaling pathway] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044281 [small molecule metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0051216 [cartilage development] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060442 [branching involved in prostate gland morphogenesis] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070487 [monocyte aggregation] GO:1900625 [positive regulation of monocyte aggregation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	742	81.5	Yes	1
CD44-002	ENSP00000278386 ENST00000278386	P16070 Show all » « Hide P16070 [Direct mapping] CD44 antigen C1PHC3 [Target identity:32%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1}	Show » « Hide CD markers Blood group antigen proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004415 [hyalurononglucosaminidase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0005975 [carbohydrate metabolic process] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016337 [single organismal cell-cell adhesion] GO:0019221 [cytokine-mediated signaling pathway] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044281 [small molecule metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0051216 [cartilage development] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070487 [monocyte aggregation] GO:1900625 [positive regulation of monocyte aggregation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	139	15.6	Yes	0
CD44-003	ENSP00000263398 ENST00000263398	P16070 Show all » « Hide P16070 [Direct mapping] CD44 antigen E9PKC6 [Target identity:21%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000435377} C1PHC3 [Target identity:12%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1} C1PHC4 [Target identity:12%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C0STK4 [Target identity:11%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1}	Show » « Hide CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004415 [hyalurononglucosaminidase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0005975 [carbohydrate metabolic process] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016337 [single organismal cell-cell adhesion] GO:0019221 [cytokine-mediated signaling pathway] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044281 [small molecule metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0051216 [cartilage development] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070487 [monocyte aggregation] GO:1900625 [positive regulation of monocyte aggregation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	361	39.4	Yes	1
CD44-004	ENSP00000389830 ENST00000415148	P16070 Show all » « Hide P16070 [Direct mapping] CD44 antigen E9PKC6 [Target identity:11%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000435377} C1PHC3 [Target identity:6%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1} C1PHC4 [Target identity:6%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} B4XHE2 [Target identity:5%; Query identity:100%] CD44 {ECO:0000313\|EMBL:ABW75083.1} C0STK4 [Target identity:5%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1} C1PHE6 [Target identity:4%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57879.1}	Show » « Hide CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004415 [hyalurononglucosaminidase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0005975 [carbohydrate metabolic process] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016337 [single organismal cell-cell adhesion] GO:0019221 [cytokine-mediated signaling pathway] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044281 [small molecule metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0051216 [cartilage development] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070487 [monocyte aggregation] GO:1900625 [positive regulation of monocyte aggregation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	699	76.6	Yes	1
CD44-005	ENSP00000392331 ENST00000433892	P16070 Show all » « Hide P16070 [Direct mapping] CD44 antigen E9PKC6 [Target identity:15%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000435377} C1PHC3 [Target identity:9%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1} C0STK4 [Target identity:8%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1} C1PHC4 [Target identity:8%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1}	Show » « Hide CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004415 [hyalurononglucosaminidase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0005975 [carbohydrate metabolic process] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016337 [single organismal cell-cell adhesion] GO:0019221 [cytokine-mediated signaling pathway] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044281 [small molecule metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0051216 [cartilage development] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070487 [monocyte aggregation] GO:1900625 [positive regulation of monocyte aggregation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	493	53.4	Yes	1
CD44-006	ENSP00000398099 ENST00000442151	C1PHC3 Show all » « Hide C1PHC3 [Target identity:15%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1} C1PHC4 [Target identity:14%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C0STK4 [Target identity:13%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005540 [hyaluronic acid binding] GO:0007155 [cell adhesion]	294	31.9	Yes	1
CD44-007	ENSP00000309732 ENST00000352818	P16070 Show all » « Hide P16070 [Direct mapping] CD44 antigen E9PKC6 [Target identity:22%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000435377} C1PHC3 [Target identity:13%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1} C1PHC4 [Target identity:12%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C0STK4 [Target identity:11%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1}	Show » « Hide CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004415 [hyalurononglucosaminidase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0005975 [carbohydrate metabolic process] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016337 [single organismal cell-cell adhesion] GO:0019221 [cytokine-mediated signaling pathway] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044281 [small molecule metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0051216 [cartilage development] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070487 [monocyte aggregation] GO:1900625 [positive regulation of monocyte aggregation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	340	37.3	Yes	1
CD44-008	ENSP00000404447 ENST00000434472	P16070 Show all » « Hide P16070 [Direct mapping] CD44 antigen E9PKC6 [Target identity:18%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000435377} C1PHC3 [Target identity:10%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1} C1PHC4 [Target identity:10%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C0STK4 [Target identity:9%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1}	Show » « Hide CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004415 [hyalurononglucosaminidase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0005975 [carbohydrate metabolic process] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016337 [single organismal cell-cell adhesion] GO:0019221 [cytokine-mediated signaling pathway] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044281 [small molecule metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0051216 [cartilage development] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070487 [monocyte aggregation] GO:1900625 [positive regulation of monocyte aggregation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	429	46.6	Yes	1
CD44-011	ENSP00000435377 ENST00000526025	E9PKC6 Show all » « Hide E9PKC6 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000435377} C1PHC3 [Target identity:57%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1}	Show » « Hide THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005540 [hyaluronic acid binding] GO:0007155 [cell adhesion]	78	8.8	Yes	0
CD44-015	ENSP00000434920 ENST00000525469	H0YE40 Show all » « Hide H0YE40 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000434920}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0007155 [cell adhesion] GO:0016020 [membrane]	82	9.1	No	0
CD44-019	ENSP00000432704 ENST00000526669	H0YD13 Show all » « Hide H0YD13 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000432704} E9PKC6 [Target identity:37%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000435377} C1PHC3 [Target identity:21%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005540 [hyaluronic acid binding] GO:0007155 [cell adhesion] GO:0016020 [membrane]	206	22.7	Yes	1
CD44-024	ENSP00000279452 ENST00000279452	H0Y2P0 Show all » « Hide H0Y2P0 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000279452} C1PHC4 [Target identity:15%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C0STK4 [Target identity:13%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005540 [hyaluronic acid binding] GO:0007155 [cell adhesion] GO:0016020 [membrane]	287	31	No	1
CD44-026	ENSP00000436451 ENST00000524922		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		118	13.5	No	0
CD44-028	ENSP00000436623 ENST00000525685	B4XHE2 Show all » « Hide B4XHE2 [Target identity:16%; Query identity:100%] CD44 {ECO:0000313\|EMBL:ABW75083.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		243	26.7	No	0
CD44-030	ENSP00000433189 ENST00000531873	C0STK4 Show all » « Hide C0STK4 [Target identity:20%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005540 [hyaluronic acid binding] GO:0007155 [cell adhesion]	195	21.2	No	0
CD44-032	ENSP00000278385 ENST00000278385	J3KN83 Show all » « Hide J3KN83 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000278385}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0007155 [cell adhesion] GO:0016020 [membrane]	232	24.7	No	1
CD44-033	ENSP00000432405 ENST00000525211	H0YCV9 Show all » « Hide H0YCV9 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000432405} C1PHC3 [Target identity:18%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1} C1PHC4 [Target identity:17%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C0STK4 [Target identity:16%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005540 [hyaluronic acid binding] GO:0007155 [cell adhesion] GO:0016020 [membrane]	249	27.3	No	0
CD44-034	ENSP00000435321 ENST00000533222	H0YEA1 Show all » « Hide H0YEA1 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000435321} B4XHE2 [Target identity:21%; Query identity:100%] CD44 {ECO:0000313\|EMBL:ABW75083.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		193	21	No	0
CD44-035	ENSP00000432718 ENST00000528455	C1PHC4 Show all » « Hide C1PHC4 [Target identity:19%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C0STK4 [Target identity:17%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1} C1PHE6 [Target identity:12%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57879.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005540 [hyaluronic acid binding] GO:0007155 [cell adhesion]	230	25.7	No	0
CD44-036	ENSP00000436980 ENST00000525688	H0YF08 Show all » « Hide H0YF08 [Target identity:99%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000436980} B4XHE2 [Target identity:21%; Query identity:100%] CD44 {ECO:0000313\|EMBL:ABW75083.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0007155 [cell adhesion] GO:0016020 [membrane]	187	20.1	No	1
CD44-037	ENSP00000431860 ENST00000528672	H0YCL4 Show all » « Hide H0YCL4 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000431860}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		195	21.5	No	0
CD44-038	ENSP00000434530 ENST00000527889	C1PHC4 Show all » « Hide C1PHC4 [Target identity:24%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C0STK4 [Target identity:22%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005540 [hyaluronic acid binding] GO:0007155 [cell adhesion]	181	19.5	No	0
CD44-039	ENSP00000436549 ENST00000531110	H0YEU1 Show all » « Hide H0YEU1 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000436549}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		249	27.3	No	0
CD44-040	ENSP00000434465 ENST00000526000	H0YDW7 Show all » « Hide H0YDW7 [Target identity:100%; Query identity:100%] CD44 antigen {ECO:0000313\|Ensembl:ENSP00000434465} C1PHC3 [Target identity:18%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57528.1} C1PHC4 [Target identity:18%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH57857.1} C0STK4 [Target identity:16%; Query identity:100%] CD44 molecule {ECO:0000313\|EMBL:BAH30705.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005540 [hyaluronic acid binding] GO:0007155 [cell adhesion] GO:0016020 [membrane]	240	26	No	0
CD44-041	ENSP00000434418 ENST00000526553		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		191	21.1	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx