MRE11A

GENERAL INFORMATION

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Gene name

MRE11A

Gene description

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA002691 , CAB004081
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MRE11A (HGNC Symbol)

Synonyms

ATLD, MRE11

Description

MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q21

Chromosome location (bp)

94415578 - 94493908

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000020922 (version 78.38)

Entrez gene

4361

UniProt

P49959 (UniProt - Evidence at protein level)

neXtProt

NX_P49959

Antibodypedia

MRE11A antibodies


PROTEIN BROWSER

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ENST00000323929
 
ENST00000323977
 
ENST00000393241
 
ENST00000407439
 
ENST00000536754
 
ENST00000538923
 
ENST00000540013
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRE11A-001 ENSP00000325863
ENST00000323929
P49959
Show all »
Show » Show » 708 80.6 No 0
MRE11A-002 ENSP00000326094
ENST00000323977
P49959
Show all »
Show » Show » 680 77.6 No 0
MRE11A-004 ENSP00000385614
ENST00000407439
B3KTC7
Show all »
Show » Show » 711 81.1 No 0
MRE11A-005 ENSP00000440986
ENST00000540013
F5GXT0
Show all »
Show » Show » 221 25 No 0
MRE11A-006 ENSP00000376933
ENST00000393241
F8W7U8
Show all »
Show » Show » 707 80.5 No 0
MRE11A-007 ENSP00000439511
ENST00000536754
F5H256
Show all »
Show » Show » 127 14.5 No 0
MRE11A-008 ENSP00000442809
ENST00000538923
F5H742
Show all »
Show » Show » 111 12.8 No 0