HGF

GENERAL INFORMATION

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Gene name

HGF

Gene description

Hepatocyte growth factor (hepapoietin A; scatter factor)

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (placenta)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression and extracellular staining at variable levels in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Data reliability

Uncertain based on 3 antibodies.
HPA040360 , HPA044088 , CAB010333
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

HGF (HGNC Symbol)

Synonyms

DFNB39, F-TCF, HGFB, HPTA, SF

Description

Hepatocyte growth factor (hepapoietin A; scatter factor) (HGNC Symbol)

Entrez gene summary

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q21.11

Chromosome location (bp)

81699006 - 81770438

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000019991 (version 78.38)

Entrez gene

3082

UniProt

P14210 (UniProt - Evidence at protein level)

neXtProt

NX_P14210

Antibodypedia

HGF antibodies


PROTEIN BROWSER

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ENST00000222390
 
ENST00000354224
 
ENST00000412881
 
ENST00000421558
 
ENST00000423064
 
ENST00000444829
 
ENST00000453018
 
ENST00000453411
 
ENST00000457544
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HGF-001 ENSP00000222390
ENST00000222390
P14210
Show all »
Show » Show » 728 83.1 Yes 0
HGF-002 ENSP00000408270
ENST00000453411
P14210
Show all »
Show » Show » 285 33.2 Yes 0
HGF-003 ENSP00000389854
ENST00000444829
P14210
Show all »
Show » Show » 290 33.8 Yes 0
HGF-004 ENSP00000413829
ENST00000423064
P14210
Show all »
Show » Show » 210 24.1 Yes 0
HGF-005 ENSP00000391238
ENST00000457544
P14210
Show all »
Show » Show » 723 82.6 Yes 0
HGF-006 ENSP00000395468
ENST00000453018
C9JJ35
Show all »
Show » 58 6.7 No 0
HGF-007 ENSP00000388592
ENST00000421558
C9JS80
Show all »
Show » 118 13.6 Yes 0
HGF-008 ENSP00000396307
ENST00000412881
C9JDP4
Show all »
Show » 141 16.2 Yes 0
HGF-201 ENSP00000346164
ENST00000354224
C9WSJ3
Show all »
Show » 184 21 Yes 0