CLDN11

GENE INFORMATION

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Gene name

CLDN11 (HGNC Symbol)

Synonyms

OSP, OTM

Description

Claudin 11 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

Chromosome

3

Cytoband

q26.2

Chromosome location (bp)

170418865 - 170860380

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000013297 (version 78.38)

Entrez gene

5010

UniProt

O75508 (UniProt - Evidence at protein level)

neXtProt

NX_O75508

Antibodypedia

CLDN11 antibodies
 

PROTEIN VIEW

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CLDN11-001
 
CLDN11-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLDN11-001 ENSP00000064724
ENST00000064724
O75508
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Show » Show » 207 22 No 4
CLDN11-002 ENSP00000417434
ENST00000486975
B4DFI2
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Show » Show » 165 18 No 3