IYD

GENE INFORMATION

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Gene name

IYD (HGNC Symbol)

Synonyms

C6orf71, DEHAL1, dJ422F24.1

Description

Iodotyrosine deiodinase (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Chromosome

6

Cytoband

q25.1

Chromosome location (bp)

150368892 - 150405969

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000009765 (version 78.38)

Entrez gene

389434

UniProt

Q6PHW0 (UniProt - Evidence at protein level)

neXtProt

NX_Q6PHW0

Antibodypedia

IYD antibodies
 

PROTEIN VIEW

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IYD-001
 
IYD-002
 
IYD-004
 
IYD-005
 
IYD-006
 
IYD-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IYD-001 ENSP00000343763
ENST00000344419
Q6PHW0
Show all »
Show » Show » 289 33.4 No 2
IYD-002 ENSP00000229447
ENST00000229447
Q6PHW0
Show all »
Show » Show » 293 33.8 No 2
IYD-004 ENSP00000376085
ENST00000392256
Q6PHW0
Show all »
Show » Show » 247 28.9 No 2
IYD-005 ENSP00000441276
ENST00000500320
F6VN83
Show all »
Show » Show » 284 32.6 No 2
IYD-006 ENSP00000376084
ENST00000392255
C9JXJ9
Show all »
Show » Show » 270 31.3 No 2
IYD-008 ENSP00000390081
ENST00000425615
F5H543
Show all »
Show » Show » 192 22.4 No 1