TFAP2B

GENERAL INFORMATION

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Gene name

TFAP2B

Gene description

Transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (adrenal gland, esophagus, kidney, salivary gland, skin)
GTEx:Tissue enhanced (breast, kidney)

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in selected tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA034683 , CAB010426
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (adrenal gland, esophagus, kidney, salivary gland, skin)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (breast, kidney)

Organ

Expression



GENE INFORMATION

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Gene name

TFAP2B (HGNC Symbol)

Synonyms

AP2-B

Description

Transcription factor AP-2 beta (activating enhancer binding protein 2 beta) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p12.3

Chromosome location (bp)

50818723 - 50847613

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000008196 (version 78.38)

Entrez gene

7021

UniProt

Q92481 (UniProt - Evidence at protein level)

neXtProt

NX_Q92481

Antibodypedia

TFAP2B antibodies


PROTEIN BROWSER

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ENST00000344788
 
ENST00000393655
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TFAP2B-001 ENSP00000377265
ENST00000393655
Q92481
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Show » Show » 460 50.5 No 0
TFAP2B-002 ENSP00000342252
ENST00000344788
X6R4Y8
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Show » Show » 198 22.1 No 0