ZFX

GENE INFORMATION

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Gene name

ZFX (HGNC Symbol)

Synonyms

ZNF926

Description

Zinc finger protein, X-linked (HGNC Symbol)

Entrez gene summary

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

Chromosome

X

Cytoband

p22.11

Chromosome location (bp)

24149173 - 24216255

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005889 (version 78.38)

Entrez gene

7543

UniProt

P17010 (UniProt - Evidence at transcript level)

neXtProt

NX_P17010

Antibodypedia

ZFX antibodies
 

PROTEIN VIEW

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ZFX-001
 
ZFX-002
 
ZFX-003
 
ZFX-007
 
ZFX-008
 
ZFX-201
 
ZFX-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ZFX-001 ENSP00000368475
ENST00000379177
P17010
Show all »
Show » Show » 805 90.5 No 0
ZFX-002 ENSP00000304985
ENST00000304543
P17010
Show all »
Show » Show » 805 90.5 No 0
ZFX-003 ENSP00000343384
ENST00000338565
E9PEP7
Show all »
Show » Show » 755 85.2 No 0
ZFX-007 ENSP00000411637
ENST00000428571
C9J682
Show all »
Show » Show » 135 14.7 No 0
ZFX-008 ENSP00000416298
ENST00000419690
C9JGU9
Show all »
Show » 32 3.5 No 0
ZFX-201 ENSP00000368486
ENST00000379188
P17010
Show all »
Show » Show » 844 94.4 No 0
ZFX-202 ENSP00000438233
ENST00000539115
P17010
Show all »
Show » Show » 576 66.1 No 0