ITGA3

GENERAL INFORMATION

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Gene name

ITGA3

Gene description

Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

Protein class

Cancer-related genes
CD markers
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Membranous expression in epithelial cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA008572 , CAB018594
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ITGA3 (HGNC Symbol)

Synonyms

CD49c, GAP-B3, MSK18, VCA-2, VLA3a

Description

Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Chromosome

17

Cytoband

q21.33

Chromosome location (bp)

50055968 - 50090481

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005884 (version 78.38)

Entrez gene

3675

UniProt

P26006 (UniProt - Evidence at protein level)

neXtProt

NX_P26006

Antibodypedia

ITGA3 antibodies


PROTEIN BROWSER

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ENST00000007722
 
ENST00000320031
 
ENST00000506827
 
ENST00000512553
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGA3-001 ENSP00000315190
ENST00000320031
P26006
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Show » Show » 1051 116.6 Yes 1
ITGA3-010 ENSP00000466652
ENST00000512553
K7EMU3
Show all »
Show » Show » 117 12.9 No 0
ITGA3-014 ENSP00000426142
ENST00000506827
Show » 221 24.6 No 0
ITGA3-020 ENSP00000007722
ENST00000007722
P26006
Show all »
Show » Show » 1066 118.8 Yes 1