MPO

GENE INFORMATION

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Gene name

MPO

Synonyms

Description

Myeloperoxidase (HGNC Symbol)

Entrez gene summary

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

Chromosome

17

Cytoband

q22

Chromosome location (bp)

58269856 - 58280935

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005381 (version 78.38)

Entrez gene

4353

UniProt

P05164 (UniProt - Evidence at protein level)

neXtProt

NX_P05164

Antibodypedia

MPO antibodies
 

PROTEIN VIEW

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MPO-001
 
MPO-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MPO-001 ENSP00000225275
ENST00000225275
P05164
Show all »
Show » Show » 745 83.9 Yes 0
MPO-005 ENSP00000464668
ENST00000577220
J3QSF7
Show all »
Show » Show » 87 9.9 No 0