KDM1A

GENERAL INFORMATION

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Gene name

KDM1A

Gene description

Lysine (K)-specific demethylase 1A

Protein class

Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB005884
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

KDM1A (HGNC Symbol)

Synonyms

AOF2, BHC110, KDM1, KIAA0601, LSD1

Description

Lysine (K)-specific demethylase 1A (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Chromosome

1

Cytoband

p36.12

Chromosome location (bp)

23019448 - 23083689

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000004487 (version 78.38)

Entrez gene

23028

UniProt

O60341 (UniProt - Evidence at protein level)

neXtProt

NX_O60341

Antibodypedia

KDM1A antibodies


PROTEIN BROWSER

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ENST00000356634
 
ENST00000400181
 
ENST00000465864
 
ENST00000494920
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KDM1A-001 ENSP00000349049
ENST00000356634
O60341
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Show » Show » 852 92.9 Yes 0
KDM1A-002 ENSP00000383042
ENST00000400181
O60341
Show all »
Show » Show » 876 95.2 Yes 0
KDM1A-004 ENSP00000473294
ENST00000494920
R4GMP9
Show all »
Show » Show » 302 32.5 No 0
KDM1A-005 ENSP00000473297
ENST00000465864
R4GMQ1
Show all »
Show » Show » 189 21.3 No 0