CFLAR - Gene info - The Human Protein Atlas

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CFLAR

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TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	CFLAR (HGNC Symbol)
Synonyms	c-FLIP, CASH, CASP8AP1, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT
Description	CASP8 and FADD-like apoptosis regulator (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	201116104 - 201176687
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000003402 (version 78.38)
Entrez gene	8837
UniProt	O15519 (UniProt - Evidence at protein level)
neXtProt	NX_O15519
Antibodypedia	CFLAR antibodies

PROTEIN VIEW

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CFLAR-001		CFLAR-002		CFLAR-003		CFLAR-005		CFLAR-006		CFLAR-007		CFLAR-008		CFLAR-010		CFLAR-011		CFLAR-012		CFLAR-015		CFLAR-016		CFLAR-017		CFLAR-018		CFLAR-021		CFLAR-022		CFLAR-023		CFLAR-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CFLAR-001	ENSP00000312455 ENST00000309955	O15519 Show all » « Hide O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 A0A024R3Z7 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator, isoform CRA_c {ECO:0000313\|EMBL:EAW70243.1} M0QYM0 [Target identity:35%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000469917} C9J408 [Target identity:26%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000411897} C9JV51 [Target identity:24%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} C9J4Q0 [Target identity:13%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:12%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002020 [protease binding] GO:0004197 [cysteine-type endopeptidase activity] GO:0005123 [death receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007519 [skeletal muscle tissue development] GO:0008047 [enzyme activator activity] GO:0008234 [cysteine-type peptidase activity] GO:0014732 [skeletal muscle atrophy] GO:0014842 [regulation of satellite cell proliferation] GO:0014866 [skeletal myofibril assembly] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0031265 [CD95 death-inducing signaling complex] GO:0032403 [protein complex binding] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403 [skeletal muscle tissue regeneration] GO:0045121 [membrane raft] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060544 [regulation of necroptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1901740 [negative regulation of myoblast fusion] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	480	55.3	No	0
CFLAR-002	ENSP00000413270 ENST00000443227	O15519 Show all » « Hide O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 M0QYM0 [Target identity:43%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000469917}	Show » « Hide Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002020 [protease binding] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007519 [skeletal muscle tissue development] GO:0008047 [enzyme activator activity] GO:0008234 [cysteine-type peptidase activity] GO:0014732 [skeletal muscle atrophy] GO:0014842 [regulation of satellite cell proliferation] GO:0014866 [skeletal myofibril assembly] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403 [skeletal muscle tissue regeneration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060544 [regulation of necroptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1901740 [negative regulation of myoblast fusion] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	384	44.1	No	0
CFLAR-003	ENSP00000339335 ENST00000341222	O15519 Show all » « Hide O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 C9J408 [Target identity:58%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000411897} C9JV51 [Target identity:53%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} M0R1A8 [Target identity:52%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000471749} C9J4Q0 [Target identity:28%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:28%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007519 [skeletal muscle tissue development] GO:0008047 [enzyme activator activity] GO:0014732 [skeletal muscle atrophy] GO:0014842 [regulation of satellite cell proliferation] GO:0014866 [skeletal myofibril assembly] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403 [skeletal muscle tissue regeneration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060544 [regulation of necroptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1901740 [negative regulation of myoblast fusion] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	221	25.4	No	0
CFLAR-005	ENSP00000378580 ENST00000395148	E9PAP3 Show all » « Hide E9PAP3 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000378580} Q59F61 [Target identity:100%; Query identity:98%] CASP8 and FADD-like apoptosis regulator variant {ECO:0000313\|EMBL:BAD92837.1} C9J408 [Target identity:51%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000411897} C9JV51 [Target identity:47%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} C9J4Q0 [Target identity:25%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:24%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process]	250	28.6	No	0
CFLAR-006	ENSP00000345807 ENST00000341582	O15519 Show all » « Hide O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 A0A024R3Y3 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator, isoform CRA_d {ECO:0000313\|EMBL:EAW70240.1} C9J408 [Target identity:28%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000411897} C9JV51 [Target identity:26%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} C9J4Q0 [Target identity:14%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:13%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002020 [protease binding] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007519 [skeletal muscle tissue development] GO:0008047 [enzyme activator activity] GO:0008234 [cysteine-type peptidase activity] GO:0014732 [skeletal muscle atrophy] GO:0014842 [regulation of satellite cell proliferation] GO:0014866 [skeletal myofibril assembly] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403 [skeletal muscle tissue regeneration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060544 [regulation of necroptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1901740 [negative regulation of myoblast fusion] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	445	51.3	No	0
CFLAR-007	ENSP00000342809 ENST00000342795	O15519 Show all » « Hide O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 M0QYM0 [Target identity:57%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000469917} C9J408 [Target identity:44%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000411897} C9JV51 [Target identity:40%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} C9J4Q0 [Target identity:21%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:21%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007519 [skeletal muscle tissue development] GO:0008047 [enzyme activator activity] GO:0014732 [skeletal muscle atrophy] GO:0014842 [regulation of satellite cell proliferation] GO:0014866 [skeletal myofibril assembly] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403 [skeletal muscle tissue regeneration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060544 [regulation of necroptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1901740 [negative regulation of myoblast fusion] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	292	33.3	No	0
CFLAR-008	ENSP00000399420 ENST00000423241	O15519 Show all » « Hide O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 A0A024R3Z7 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator, isoform CRA_c {ECO:0000313\|EMBL:EAW70243.1} M0QYM0 [Target identity:35%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000469917} C9J408 [Target identity:26%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000411897} C9JV51 [Target identity:24%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} C9J4Q0 [Target identity:13%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:12%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002020 [protease binding] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007519 [skeletal muscle tissue development] GO:0008047 [enzyme activator activity] GO:0008234 [cysteine-type peptidase activity] GO:0014732 [skeletal muscle atrophy] GO:0014842 [regulation of satellite cell proliferation] GO:0014866 [skeletal myofibril assembly] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403 [skeletal muscle tissue regeneration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060544 [regulation of necroptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1901740 [negative regulation of myoblast fusion] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	480	55.3	No	0
CFLAR-010	ENSP00000406775 ENST00000440180	O15519 Show all » « Hide O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 C9J408 [Target identity:58%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000411897} C9JV51 [Target identity:53%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} M0R1A8 [Target identity:52%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000471749} C9J4Q0 [Target identity:28%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:28%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007519 [skeletal muscle tissue development] GO:0008047 [enzyme activator activity] GO:0014732 [skeletal muscle atrophy] GO:0014842 [regulation of satellite cell proliferation] GO:0014866 [skeletal myofibril assembly] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403 [skeletal muscle tissue regeneration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060544 [regulation of necroptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1901740 [negative regulation of myoblast fusion] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	221	25.4	No	0
CFLAR-011	ENSP00000411535 ENST00000457277	O15519 Show all » « Hide O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 M0QYM0 [Target identity:36%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000469917} C9J408 [Target identity:27%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000411897} C9JV51 [Target identity:25%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} C9J4Q0 [Target identity:13%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:13%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002020 [protease binding] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007519 [skeletal muscle tissue development] GO:0008047 [enzyme activator activity] GO:0008234 [cysteine-type peptidase activity] GO:0014732 [skeletal muscle atrophy] GO:0014842 [regulation of satellite cell proliferation] GO:0014866 [skeletal myofibril assembly] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403 [skeletal muscle tissue regeneration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060544 [regulation of necroptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1901740 [negative regulation of myoblast fusion] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	462	52.6	No	0
CFLAR-012	ENSP00000471805 ENST00000479953	O15519 Show all » « Hide O15519 [Direct mapping] CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 M0QYM0 [Target identity:45%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000469917}	Show » « Hide Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002020 [protease binding] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007519 [skeletal muscle tissue development] GO:0008047 [enzyme activator activity] GO:0008234 [cysteine-type peptidase activity] GO:0014732 [skeletal muscle atrophy] GO:0014842 [regulation of satellite cell proliferation] GO:0014866 [skeletal myofibril assembly] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043403 [skeletal muscle tissue regeneration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060544 [regulation of necroptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1901740 [negative regulation of myoblast fusion] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	366	41.3	No	0
CFLAR-015	ENSP00000411897 ENST00000441224	C9J408 Show all » « Hide C9J408 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000411897} C9JV51 [Target identity:91%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} C9J4Q0 [Target identity:49%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:48%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process]	129	15	No	0
CFLAR-016	ENSP00000391029 ENST00000433445	C9J4Q0 Show all » « Hide C9J4Q0 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:96%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process]	64	7.4	No	0
CFLAR-017	ENSP00000409570 ENST00000425030	C9JSU3 Show all » « Hide C9JSU3 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process]	62	7.1	No	0
CFLAR-018	ENSP00000412882 ENST00000417748	C9JV51 Show all » « Hide C9JV51 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000412882} C9J4Q0 [Target identity:54%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000391029} C9JSU3 [Target identity:52%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000409570}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process]	118	13.7	No	0
CFLAR-021	ENSP00000469608 ENST00000494258	M0QY57 Show all » « Hide M0QY57 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000469608}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process]	117	13.2	No	0
CFLAR-022	ENSP00000471749 ENST00000470178	M0R1A8 Show all » « Hide M0R1A8 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000471749}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process]	117	13.3	No	0
CFLAR-023	ENSP00000469917 ENST00000462763	M0QYM0 Show all » « Hide M0QYM0 [Target identity:100%; Query identity:100%] CASP8 and FADD-like apoptosis regulator {ECO:0000313\|Ensembl:ENSP00000469917}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0042981 [regulation of apoptotic process]	168	19.1	No	0
CFLAR-201	ENSP00000339326 ENST00000340870		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008234 [cysteine-type peptidase activity] GO:0042981 [regulation of apoptotic process]	321	36.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.