CYP51A1

GENE INFORMATION

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Gene name

CYP51A1 (HGNC Symbol)

Synonyms

CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1

Description

Cytochrome P450, family 51, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

7

Cytoband

q21.2

Chromosome location (bp)

92112151 - 92142952

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000001630 (version 78.38)

Entrez gene

1595

UniProt

Q16850 (UniProt - Evidence at protein level)

neXtProt

NX_Q16850

Antibodypedia

CYP51A1 antibodies
 

PROTEIN VIEW

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CYP51A1-001
 
CYP51A1-002
 
CYP51A1-005
 
CYP51A1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP51A1-001 ENSP00000003100
ENST00000003100
Q16850
Show all »
Show » Show » 509 57.3 Yes 1
CYP51A1-002 ENSP00000406757
ENST00000450723
Q16850
Show all »
Show » Show » 404 46.3 No 0
CYP51A1-005 ENSP00000412536
ENST00000435873
C9IYR8
Show all »
Show » 30 3.4 No 0
CYP51A1-006 ENSP00000394268
ENST00000422867
Show » Show » 222 25.5 No 0