FGR - Gene info - The Human Protein Atlas

Gene name

FGR (HGNC Symbol)

Synonyms

c-fgr, p55c-fgr, SRC2

Description

FGR proto-oncogene, Src family tyrosine kinase (HGNC Symbol)

Entrez gene summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p35.3

Chromosome location (bp)

27612064 - 27635277

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000000938 (version 78.38)

Entrez gene

2268

UniProt

P09769 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGR-001

ENSP00000363117
ENST00000374005

P09769
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P09769 [Direct mapping]
Tyrosine-protein kinase Fgr
Q5TGY6 [Target identity:58%; Query identity:100%]
Tyrosine-protein kinase Fgr {ECO:0000313|Ensembl:ENSP00000407670}
P78453 [Target identity:33%; Query identity:100%]
Tyrosine kinase {ECO:0000313|EMBL:AAA35679.1}
P78483 [Target identity:21%; Query identity:100%]
C-src-2 protein {ECO:0000313|EMBL:AAA60585.1}
Q7KZ45 [Target identity:7%; Query identity:100%]
Fgr proto-oncogene encoded p55-c-fgr protein, partial exons 2 and 3 {ECO:0000313|EMBL:AAA52452.1}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cytoskeleton related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001784 [phosphotyrosine binding]
GO:0002768 [immune response-regulating cell surface receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008360 [regulation of cell shape]
GO:0009615 [response to virus]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015629 [actin cytoskeleton]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0032587 [ruffle membrane]
GO:0034987 [immunoglobulin receptor binding]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045859 [regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular vesicular exosome]

529

59.5

FGR-002

ENSP00000363115
ENST00000374003

P09769
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529

59.5

FGR-004

ENSP00000363116
ENST00000374004

P09769
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529

59.5

FGR-007

ENSP00000407670
ENST00000457296

Q5TGY6
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Q5TGY6 [Target identity:99%; Query identity:100%]
Tyrosine-protein kinase Fgr {ECO:0000313|Ensembl:ENSP00000407670}
P78453 [Target identity:56%; Query identity:100%]
Tyrosine kinase {ECO:0000313|EMBL:AAA35679.1}
Q7KZ45 [Target identity:12%; Query identity:100%]
Fgr proto-oncogene encoded p55-c-fgr protein, partial exons 2 and 3 {ECO:0000313|EMBL:AAA52452.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0045087 [innate immune response]

313

34.7

FGR-201

ENSP00000382126
ENST00000399173

P09769
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529

59.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.