KIR2DL3

GENE INFORMATION

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Gene name

KIR2DL3 (HGNC Symbol)

Synonyms

CD158B2, cl-6, nkat2, nkat2a, nkat2b, p58

Description

Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 (HGNC Symbol)

Entrez gene summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.42

Chromosome location (bp)

54724459 - 54767884

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000243772 (version 78.38)

Entrez gene

3804

UniProt

P43628 (UniProt - Evidence at protein level)

neXtProt

NX_P43628

Antibodypedia

KIR2DL3 antibodies
 

PROTEIN VIEW

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KIR2DL3-001
 
KIR2DL3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KIR2DL3-001 ENSP00000342215
ENST00000342376
P43628
Show all »
Show » Show » 341 37.9 Yes 1
KIR2DL3-201 ENSP00000415758
ENST00000434419
Show » 349 38.6 Yes 1