MAFK

GENE INFORMATION

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Gene name

MAFK (HGNC Symbol)

Synonyms

NFE2U, P18

Description

V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (HGNC Symbol)

Entrez gene summary

The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]

Chromosome

7

Cytoband

p22.3

Chromosome location (bp)

1530714 - 1543043

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198517 (version 78.38)

Entrez gene

7975

UniProt

O60675 (UniProt - Evidence at protein level)

neXtProt

NX_O60675

Antibodypedia

MAFK antibodies
 

PROTEIN VIEW

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MAFK-001
 
MAFK-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAFK-001 ENSP00000344903
ENST00000343242
O60675
Show all »
Show » Show » 156 17.5 No 0
MAFK-003 ENSP00000385437
ENST00000406174
O60675
Show all »
Show » Show » 156 17.5 No 0