MAPT - Gene info - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. Don't show this again.

MAPT

premium

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

? »

Gene name	MAPT (HGNC Symbol)
Synonyms	DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau
Description	Microtubule-associated protein tau (HGNC Symbol)
Entrez gene summary	This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	45894382 - 46028334
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186868 (version 78.38)
Entrez gene	4137
UniProt	P10636 (UniProt - Evidence at protein level)
neXtProt	NX_P10636
Antibodypedia	MAPT antibodies

PROTEIN VIEW

? »

MAPT-001		MAPT-002		MAPT-003		MAPT-004		MAPT-006		MAPT-007		MAPT-008		MAPT-009		MAPT-201		MAPT-202		MAPT-203		MAPT-204		MAPT-205

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
MAPT-001	ENSP00000334886 ENST00000334239	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau B4DSE3 [Target identity:45%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686}	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	352	36.8	No	0
MAPT-002	ENSP00000408975 ENST00000446361	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau A0A024R9Y0 [Target identity:100%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686}	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	383	40	No	0
MAPT-003	ENSP00000413056 ENST00000420682	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	412	43	No	0
MAPT-004	ENSP00000410838 ENST00000415613	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	776	80.9	No	0
MAPT-006	ENSP00000389250 ENST00000431008	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau B4DSE3 [Target identity:39%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686}	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	410	42.6	No	0
MAPT-007	ENSP00000460965 ENST00000574436	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau A0A024RA17 [Target identity:100%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686}	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	441	45.8	No	0
MAPT-008	ENSP00000458742 ENST00000571987	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau A0A024R9Y1 [Target identity:100%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686}	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	758	78.9	No	0
MAPT-009	ENSP00000458621 ENST00000576518	I3L170 Show all » « Hide I3L170 [Target identity:100%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686} B4DSE3 [Target identity:47%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0015631 [tubulin binding]	341	35.7	No	0
MAPT-201	ENSP00000262410 ENST00000262410	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau A0A024R9Y1 [Target identity:100%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686}	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	758	78.9	No	0
MAPT-202	ENSP00000340438 ENST00000340799	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	412	43	No	0
MAPT-203	ENSP00000340820 ENST00000344290	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0001764 [neuron migration] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0005930 [axoneme] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007409 [axonogenesis] GO:0007628 [adult walking behavior] GO:0008017 [microtubule binding] GO:0008088 [axon cargo transport] GO:0010506 [regulation of autophagy] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0032387 [negative regulation of intracellular transport] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0047497 [mitochondrion transport along microtubule] GO:0048675 [axon extension] GO:0048699 [generation of neurons] GO:0060632 [regulation of microtubule-based movement] GO:0071813 [lipoprotein particle binding]	776	80.9	No	0
MAPT-204	ENSP00000303214 ENST00000351559	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau A0A024RA17 [Target identity:100%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686}	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	441	45.8	No	0
MAPT-205	ENSP00000443028 ENST00000535772	P10636 Show all » « Hide P10636 [Direct mapping] Microtubule-associated protein tau B4DSE3 [Target identity:39%; Query identity:100%] Microtubule-associated protein {ECO:0000256\|RuleBase:RU000686}	Show » « Hide Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0015631 [tubulin binding] GO:0017124 [SH3 domain binding] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048699 [generation of neurons] GO:0071813 [lipoprotein particle binding]	410	42.6	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.