KRT6B

GENE INFORMATION

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Gene name

KRT6B (HGNC Symbol)

Synonyms

KRTL1

Description

Keratin 6B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

52446651 - 52452126

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185479 (version 78.38)

Entrez gene

3854

UniProt

P04259 (UniProt - Evidence at protein level)

neXtProt

NX_P04259

Antibodypedia

KRT6B antibodies
 

PROTEIN VIEW

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KRT6B-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRT6B-001 ENSP00000252252
ENST00000252252
P04259
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