GALR2

GENE INFORMATION

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Gene name

GALR2 (HGNC Symbol)

Synonyms

GALNR2

Description

Galanin receptor 2 (HGNC Symbol)

Entrez gene summary

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q25.1

Chromosome location (bp)

76074794 - 76077541

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182687 (version 78.38)

Entrez gene

8811

UniProt

O43603 (UniProt - Evidence at protein level)

neXtProt

NX_O43603

Antibodypedia

GALR2 antibodies
 

PROTEIN VIEW

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GALR2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GALR2-001 ENSP00000329684
ENST00000329003
O43603
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