E2F7 - Gene info - The Human Protein Atlas

Gene name

E2F7

Synonyms

Description

E2F transcription factor 7 (HGNC Symbol)

Entrez gene summary

E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008]

Chromosome

Cytoband

q21.2

Chromosome location (bp)

77021247 - 77065580

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165891 (version 78.38)

Entrez gene

144455

UniProt

Q96AV8 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

E2F7-001

ENSP00000323246
ENST00000322886

Q96AV8
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Q96AV8 [Direct mapping]
Transcription factor E2F7
F8VSE7 [Target identity:76%; Query identity:100%]
Transcription factor E2F7 {ECO:0000313|Ensembl:ENSP00000448245}
F8VXV5 [Target identity:12%; Query identity:100%]
Transcription factor E2F7 {ECO:0000313|Ensembl:ENSP00000449033}

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Predicted intracellular proteins
Transcription factors
Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001227 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription]
GO:0001890 [placenta development]
GO:0002040 [sprouting angiogenesis]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008285 [negative regulation of cell proliferation]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0032466 [negative regulation of cytokinesis]
GO:0032877 [positive regulation of DNA endoreduplication]
GO:0042802 [identical protein binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060718 [chorionic trophoblast cell differentiation]
GO:0070365 [hepatocyte differentiation]
GO:0071930 [negative regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]

911

99.9

E2F7-003

ENSP00000448245
ENST00000550669

F8VSE7
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F8VSE7 [Target identity:100%; Query identity:100%]
Transcription factor E2F7 {ECO:0000313|Ensembl:ENSP00000448245}
F8VXV5 [Target identity:16%; Query identity:100%]
Transcription factor E2F7 {ECO:0000313|Ensembl:ENSP00000449033}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]

693

77.1

E2F7-004

ENSP00000393639
ENST00000416496

Q96AV8
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Q96AV8 [Direct mapping]
Transcription factor E2F7
F8VSE7 [Target identity:95%; Query identity:100%]
Transcription factor E2F7 {ECO:0000313|Ensembl:ENSP00000448245}
F8VXV5 [Target identity:15%; Query identity:100%]
Transcription factor E2F7 {ECO:0000313|Ensembl:ENSP00000449033}

Show » « Hide

Predicted intracellular proteins
Transcription factors
Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001047 [core promoter binding]
GO:0001890 [placenta development]
GO:0002040 [sprouting angiogenesis]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008285 [negative regulation of cell proliferation]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0032466 [negative regulation of cytokinesis]
GO:0032877 [positive regulation of DNA endoreduplication]
GO:0042802 [identical protein binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060718 [chorionic trophoblast cell differentiation]
GO:0070365 [hepatocyte differentiation]
GO:0071930 [negative regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]

728

80.9

E2F7-005

ENSP00000449033
ENST00000547316

F8VXV5
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F8VXV5 [Target identity:100%; Query identity:100%]
Transcription factor E2F7 {ECO:0000313|Ensembl:ENSP00000449033}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

115

13.3

E2F7-007

ENSP00000449284
ENST00000551058

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]

219

25.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.