MST1R

GENE INFORMATION

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Gene name

MST1R (HGNC Symbol)

Synonyms

CD136, CDw136, PTK8, RON

Description

Macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (HGNC Symbol)

Entrez gene summary

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

49887002 - 49903873

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164078 (version 78.38)

Entrez gene

4486

UniProt

Q04912 (UniProt - Evidence at protein level)

neXtProt

NX_Q04912

Antibodypedia

MST1R antibodies
 

PROTEIN VIEW

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MST1R-001
 
MST1R-002
 
MST1R-010
 
MST1R-011
 
MST1R-201
 
MST1R-202
 
MST1R-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MST1R-001 ENSP00000296474
ENST00000296474
Q04912
Show all »
Show » Show » 1400 152.2 Yes 1
MST1R-002 ENSP00000341325
ENST00000344206
Q04912
Show all »
Show » Show » 1351 147.2 Yes 1
MST1R-010 ENSP00000414792
ENST00000440292
Show » Show » 270 30 No 0
MST1R-011 ENSP00000393294
ENST00000434765
Show » Show » 285 32.3 No 1
MST1R-201 ENSP00000481084
ENST00000612032
H2E272
Show all »
Show » Show » 254 29.4 No 0
MST1R-202 ENSP00000482827
ENST00000613534
Show » Show » 574 62.3 Yes 1
MST1R-203 ENSP00000482642
ENST00000621387
B4E058
Show all »
Show » Show » 1294 140.7 Yes 1