GFI1 - Gene info - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. Don't show this again.

GFI1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

? »

Gene name	GFI1 (HGNC Symbol)
Synonyms	GFI-1, GFI1A, ZNF163
Description	Growth factor independent 1 transcription repressor (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p22.1
Chromosome location (bp)	92474762 - 92486876
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162676 (version 78.38)
Entrez gene	2672
UniProt	Q99684 (UniProt - Evidence at protein level)
neXtProt	NX_Q99684
Antibodypedia	GFI1 antibodies

PROTEIN VIEW

? »

GFI1-001		GFI1-002		GFI1-201

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
GFI1-001	ENSP00000359357 ENST00000370332	Q99684 Show all » « Hide Q99684 [Direct mapping] Zinc finger protein Gfi-1 D3DT36 [Target identity:75%; Query identity:100%] Growth factor independent 1, isoform CRA_a {ECO:0000313\|EMBL:EAW73093.1}	Show » « Hide Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes	Show » « Hide GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007638 [mechanosensory behavior] GO:0008270 [zinc ion binding] GO:0009996 [negative regulation of cell fate specification] GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity] GO:0010957 [negative regulation of vitamin D biosynthetic process] GO:0010977 [negative regulation of neuron projection development] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016604 [nuclear body] GO:0017053 [transcriptional repressor complex] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0042472 [inner ear morphogenesis] GO:0042491 [auditory receptor cell differentiation] GO:0042660 [positive regulation of cell fate specification] GO:0044212 [transcription regulatory region DNA binding] GO:0045165 [cell fate commitment] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0070105 [positive regulation of interleukin-6-mediated signaling pathway] GO:0071222 [cellular response to lipopolysaccharide]	422	45.3	No	0
GFI1-002	ENSP00000294702 ENST00000294702	Q99684 Show all » « Hide Q99684 [Direct mapping] Zinc finger protein Gfi-1 D3DT36 [Target identity:75%; Query identity:100%] Growth factor independent 1, isoform CRA_a {ECO:0000313\|EMBL:EAW73093.1}	Show » « Hide Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes	Show » « Hide GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity] GO:0010957 [negative regulation of vitamin D biosynthetic process] GO:0010977 [negative regulation of neuron projection development] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016604 [nuclear body] GO:0017053 [transcriptional repressor complex] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0070105 [positive regulation of interleukin-6-mediated signaling pathway] GO:0071222 [cellular response to lipopolysaccharide]	422	45.3	No	0
GFI1-201	ENSP00000399719 ENST00000427103	Q99684 Show all » « Hide Q99684 [Direct mapping] Zinc finger protein Gfi-1 D3DT36 [Target identity:75%; Query identity:100%] Growth factor independent 1, isoform CRA_a {ECO:0000313\|EMBL:EAW73093.1}	Show » « Hide Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes	Show » « Hide GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity] GO:0010957 [negative regulation of vitamin D biosynthetic process] GO:0010977 [negative regulation of neuron projection development] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016604 [nuclear body] GO:0017053 [transcriptional repressor complex] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0070105 [positive regulation of interleukin-6-mediated signaling pathway] GO:0071222 [cellular response to lipopolysaccharide]	422	45.3	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.