DNMT3L

GENE INFORMATION

? »

Gene name

DNMT3L (HGNC Symbol)

Synonyms

MGC1090

Description

DNA (cytosine-5-)-methyltransferase 3-like (HGNC Symbol)

Entrez gene summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

44246339 - 44262216

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142182 (version 78.38)

Entrez gene

29947

UniProt

Q9UJW3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UJW3

Antibodypedia

DNMT3L antibodies
 

PROTEIN VIEW

? »
 
 
 
DNMT3L-001
 
DNMT3L-002
 
DNMT3L-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DNMT3L-001 ENSP00000270172
ENST00000270172
Q9UJW3
Show all »
Show » Show » 387 43.7 No 0
DNMT3L-002 ENSP00000400242
ENST00000431166
C9J0T5
Show all »
Show » 288 32.4 No 0
DNMT3L-003 ENSP00000411608
ENST00000436357
Show » 181 20.4 No 0