ARRB1

GENE INFORMATION

? »

Gene name

ARRB1 (HGNC Symbol)

Synonyms

ARR1

Description

Arrestin, beta 1 (HGNC Symbol)

Entrez gene summary

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

Chromosome

11

Cytoband

q13.4

Chromosome location (bp)

75264182 - 75351705

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137486 (version 78.38)

Entrez gene

408

UniProt

P49407 (UniProt - Evidence at protein level)

neXtProt

NX_P49407

Antibodypedia

ARRB1 antibodies
 

PROTEIN VIEW

? »
 
 
 
ARRB1-001
 
ARRB1-002
 
ARRB1-006
 
ARRB1-012
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARRB1-001 ENSP00000409581
ENST00000420843
P49407
Show all »
Show » Show » 418 47.1 No 0
ARRB1-002 ENSP00000353124
ENST00000360025
P49407
Show all »
Show » Show » 410 46.3 No 0
ARRB1-006 ENSP00000433171
ENST00000532525
E9PM35
Show all »
Show » Show » 258 29.2 No 0
ARRB1-012 ENSP00000436530
ENST00000532447
Show » 195 21.8 No 0