GAD2

GENE INFORMATION

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Gene name

GAD2 (HGNC Symbol)

Synonyms

GAD65

Description

Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (HGNC Symbol)

Entrez gene summary

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

Chromosome

10

Cytoband

p12.1

Chromosome location (bp)

26216307 - 26304558

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136750 (version 78.38)

Entrez gene

2572

UniProt

Q05329 (UniProt - Evidence at protein level)

neXtProt

NX_Q05329

Antibodypedia

GAD2 antibodies
 

PROTEIN VIEW

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GAD2-001
 
GAD2-002
 
GAD2-003
 
GAD2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GAD2-001 ENSP00000365437
ENST00000376261
Q05329
Show all »
Show » Show » 585 65.4 No 0
GAD2-002 ENSP00000259271
ENST00000259271
Q05329
Show all »
Show » Show » 585 65.4 No 0
GAD2-003 ENSP00000390434
ENST00000428517
Q5VZ31
Show all »
Show » 188 20.6 No 0
GAD2-004 ENSP00000365424
ENST00000376248
Q5VZ29
Show all »
Show » Show » 129 14.8 No 0