MTHFS

GENE INFORMATION

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Gene name

MTHFS (HGNC Symbol)

Synonyms

HsT19268

Description

5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

15

Cytoband

q25.1

Chromosome location (bp)

79833585 - 79897379

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136371 (version 78.38)

Entrez gene

10588

UniProt

P49914 (UniProt - Evidence at protein level)

neXtProt

NX_P49914

Antibodypedia

MTHFS antibodies
 

PROTEIN VIEW

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MTHFS-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MTHFS-001 ENSP00000258874
ENST00000258874
P49914
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