IVD

GENE INFORMATION

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Gene name

IVD (HGNC Symbol)

Synonyms

ACAD2

Description

Isovaleryl-CoA dehydrogenase (HGNC Symbol)

Entrez gene summary

Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Chromosome

15

Cytoband

q15.1

Chromosome location (bp)

40405795 - 40435947

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128928 (version 78.38)

Entrez gene

3712

UniProt

P26440 (UniProt - Evidence at protein level)

neXtProt

NX_P26440

Antibodypedia

IVD antibodies
 

PROTEIN VIEW

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IVD-001
 
IVD-002
 
IVD-004
 
IVD-006
 
IVD-008
 
IVD-009
 
IVD-012
 
IVD-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IVD-001 ENSP00000418397
ENST00000487418
O43577
Show all »
Show » Show » 426 46.7 No 0
IVD-002 ENSP00000417990
ENST00000479013
P26440
Show all »
Show » Show » 396 43.1 No 0
IVD-004 ENSP00000479359
ENST00000610693
O43577
Show all »
Show » Show » 214 23.3 No 0
IVD-006 ENSP00000417256
ENST00000473112
Show » Show » 307 32.8 No 0
IVD-008 ENSP00000454145
ENST00000466756
Show » 58 6.2 No 0
IVD-009 ENSP00000453146
ENST00000491554
H0YLC3
Show all »
Show » Show » 243 26.4 No 0
IVD-012 ENSP00000453929
ENST00000559575
Show » 41 4.1 No 0
IVD-013 ENSP00000453821
ENST00000558610
H0YN10
Show all »
Show » Show » 212 23.4 No 0