OGG1

GENE INFORMATION

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Gene name

OGG1 (HGNC Symbol)

Synonyms

HMMH, HOGG1, MUTM, OGH1

Description

8-oxoguanine DNA glycosylase (HGNC Symbol)

Entrez gene summary

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

Chromosome

3

Cytoband

p25.3

Chromosome location (bp)

9749944 - 9788219

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114026 (version 78.38)

Entrez gene

4968

UniProt

O15527 (UniProt - Evidence at protein level)

neXtProt

NX_O15527

Antibodypedia

OGG1 antibodies
 

PROTEIN VIEW

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OGG1-001
 
OGG1-002
 
OGG1-003
 
OGG1-004
 
OGG1-005
 
OGG1-006
 
OGG1-007
 
OGG1-008
 
OGG1-010
 
OGG1-013
 
OGG1-016
 
OGG1-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OGG1-001 ENSP00000306561
ENST00000302036
O15527
Show all »
Show » Show » 424 47.2 No 0
OGG1-002 ENSP00000342851
ENST00000344629
O15527
Show all »
Show » Show » 345 38.8 No 0
OGG1-003 ENSP00000305584
ENST00000302003
O15527
Show all »
Show » Show » 410 45.8 No 0
OGG1-004 ENSP00000344899
ENST00000352937
Show » Show » 263 29 No 0
OGG1-005 ENSP00000373337
ENST00000383826
O15527
Show all »
Show » Show » 195 22.2 No 0
OGG1-006 ENSP00000305527
ENST00000302008
O15527
Show all »
Show » Show » 356 40.1 No 0
OGG1-007 ENSP00000345520
ENST00000339511
O15527
Show all »
Show » Show » 324 36.4 No 0
OGG1-008 ENSP00000403598
ENST00000449570
O15527
Show all »
Show » Show » 322 36.1 No 0
OGG1-010 ENSP00000402713
ENST00000416333
Show » Show » 132 14.6 No 0
OGG1-013 ENSP00000390337
ENST00000441094
Show » Show » 222 24.4 Yes 0
OGG1-016 ENSP00000399810
ENST00000426518
Show » Show » 128 14.3 No 0
OGG1-201 ENSP00000303132
ENST00000349503
O15527
Show all »
Show » Show » 357 39.7 No 0