SLC1A2

GENE INFORMATION

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Gene name

SLC1A2 (HGNC Symbol)

Synonyms

EAAT2, GLT-1

Description

Solute carrier family 1 (glial high affinity glutamate transporter), member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]

Chromosome

11

Cytoband

p13

Chromosome location (bp)

35251206 - 35420063

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110436 (version 78.38)

Entrez gene

6506

UniProt

P43004 (UniProt - Evidence at protein level)

neXtProt

NX_P43004

Antibodypedia

SLC1A2 antibodies
 

PROTEIN VIEW

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SLC1A2-001
 
SLC1A2-002
 
SLC1A2-003
 
SLC1A2-004
 
SLC1A2-006
 
SLC1A2-007
 
SLC1A2-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC1A2-001 ENSP00000278379
ENST00000278379
P43004
Show all »
Show » Show » 574 62.1 No >9
SLC1A2-002 ENSP00000379102
ENST00000395753
P43004
Show all »
Show » Show » 565 61.2 No >9
SLC1A2-003 ENSP00000435406
ENST00000464522
H0YEB1
Show all »
Show » Show » 91 10.1 No 0
SLC1A2-004 ENSP00000379099
ENST00000395750
P43004
Show all »
Show » Show » 565 61.2 No >9
SLC1A2-006 ENSP00000406133
ENST00000449068
C9J9N5
Show all »
Show » Show » 199 21.5 No 3
SLC1A2-007 ENSP00000436029
ENST00000531628
Show » Show » 199 21.7 No 3
SLC1A2-008 ENSP00000476124
ENST00000606205
P43004
Show all »
Show » Show » 563 61 No >9