CAPN3 - Gene info - The Human Protein Atlas

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CAPN3

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TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	CAPN3 (HGNC Symbol)
Synonyms	CANP3, LGMD2, LGMD2A, nCL-1, p94
Description	Calpain 3, (p94) (HGNC Symbol)
Entrez gene summary	Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	42359500 - 42412318
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000092529 (version 78.38)
Entrez gene	825
UniProt	P20807 (UniProt - Evidence at protein level)
neXtProt	NX_P20807
Antibodypedia	CAPN3 antibodies

PROTEIN VIEW

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CAPN3-005		CAPN3-006		CAPN3-007		CAPN3-008		CAPN3-009		CAPN3-010		CAPN3-011		CAPN3-012		CAPN3-013		CAPN3-015		CAPN3-017		CAPN3-019		CAPN3-201		CAPN3-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CAPN3-005	ENSP00000183936 ENST00000349748	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BMH1 [Target identity:34%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000454379} H3BS30 [Target identity:12%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	729	84.1	No	0
CAPN3-006	ENSP00000336840 ENST00000337571	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:59%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	156	18.2	No	0
CAPN3-007	ENSP00000380384 ENST00000397200	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:30%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	309	35.9	No	0
CAPN3-008	ENSP00000350181 ENST00000357568	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:11%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	815	93.5	No	0
CAPN3-009	ENSP00000380349 ENST00000397163	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:11%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001896 [autolysis] GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045661 [regulation of myoblast differentiation] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0070315 [G1 to G0 transition involved in cell differentiation] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	821	94.3	No	0
CAPN3-010	ENSP00000454379 ENST00000569827	H3BMH1 Show all » « Hide H3BMH1 [Target identity:99%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000454379}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0006508 [proteolysis] GO:0045214 [sarcomere organization]	256	29.9	No	0
CAPN3-011	ENSP00000456607 ENST00000567071		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		188	21.5	No	0
CAPN3-012	ENSP00000380387 ENST00000397204	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:59%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	156	18.2	No	0
CAPN3-013	ENSP00000456575 ENST00000561817	H3BS77 Show all » « Hide H3BS77 [Target identity:100%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456575} A4FTZ9 [Target identity:91%; Query identity:100%] CAPN3 protein {ECO:0000313\|EMBL:AAI00784.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0006508 [proteolysis] GO:0045214 [sarcomere organization]	191	22	No	0
CAPN3-015	ENSP00000455254 ENST00000569136	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:59%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	156	18.2	No	0
CAPN3-017	ENSP00000457878 ENST00000565559	H3BUZ3 Show all » « Hide H3BUZ3 [Target identity:100%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000457878}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0006508 [proteolysis] GO:0045214 [sarcomere organization]	157	17.6	No	0
CAPN3-019	ENSP00000457898 ENST00000564503		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding]	169	19.5	No	0
CAPN3-201	ENSP00000326281 ENST00000318023	H3BS30 Show all » « Hide H3BS30 [Target identity:12%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0006508 [proteolysis]	773	89	No	0
CAPN3-202	ENSP00000348667 ENST00000356316	P20807 Show all » « Hide P20807 [Direct mapping] Calpain-3 H3BS30 [Target identity:59%; Query identity:100%] Calpain-3 {ECO:0000313\|Ensembl:ENSP00000456514}	Show » « Hide Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]	156	18.2	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.