TBXAS1

GENE INFORMATION

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Gene name

TBXAS1 (HGNC Symbol)

Synonyms

CYP5, CYP5A1, THAS, TS, TXAS, TXS

Description

Thromboxane A synthase 1 (platelet) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

7

Cytoband

q34

Chromosome location (bp)

139777051 - 140020325

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000059377 (version 78.38)

Entrez gene

6916

UniProt

P24557 (UniProt - Evidence at protein level)

neXtProt

NX_P24557

Antibodypedia

TBXAS1 antibodies
 

PROTEIN VIEW

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TBXAS1-001
 
TBXAS1-002
 
TBXAS1-003
 
TBXAS1-004
 
TBXAS1-005
 
TBXAS1-008
 
TBXAS1-011
 
TBXAS1-201
 
TBXAS1-202
 
TBXAS1-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TBXAS1-001 ENSP00000338087
ENST00000336425
P24557
Show all »
Show » Show » 533 60.5 No 2
TBXAS1-002 ENSP00000388736
ENST00000425687
P24557
Show all »
Show » Show » 466 53 No 0
TBXAS1-003 ENSP00000402536
ENST00000448866
P24557
Show all »
Show » Show » 533 60.5 No 2
TBXAS1-004 ENSP00000411274
ENST00000458722
P24557
Show all »
Show » Show » 579 65.6 No 2
TBXAS1-005 ENSP00000411326
ENST00000411653
P24557
Show all »
Show » Show » 459 52.3 No 1
TBXAS1-008 ENSP00000391567
ENST00000455353
E7EP75
Show all »
Show » Show » 151 17.3 No 1
TBXAS1-011 ENSP00000388612
ENST00000438104
C9JS68
Show all »
Show » Show » 150 17.2 No 1
TBXAS1-201 ENSP00000263552
ENST00000263552
Q53F23
Show all »
Show » Show » 534 60.6 No 2
TBXAS1-202 ENSP00000392702
ENST00000414508
C9JS68
Show all »
Show » Show » 460 52.4 No 1
TBXAS1-203 ENSP00000389414
ENST00000416849
P24557
Show all »
Show » Show » 580 65.8 No 2