MGST1

GENE INFORMATION

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Gene name

MGST1 (HGNC Symbol)

Synonyms

GST12, MGST-I

Description

Microsomal glutathione S-transferase 1 (HGNC Symbol)

Entrez gene summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

12

Cytoband

p12.3

Chromosome location (bp)

16347142 - 16609259

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000008394 (version 78.38)

Entrez gene

4257

UniProt

P10620 (UniProt - Evidence at protein level)

neXtProt

NX_P10620

Antibodypedia

MGST1 antibodies
 

PROTEIN VIEW

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MGST1-001
 
MGST1-002
 
MGST1-004
 
MGST1-005
 
MGST1-006
 
MGST1-007
 
MGST1-009
 
MGST1-013
 
MGST1-201
 
MGST1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MGST1-001 ENSP00000379513
ENST00000396210
P10620
Show all »
Show » Show » 155 17.6 No 4
MGST1-002 ENSP00000379510
ENST00000396207
P10620
Show all »
Show » Show » 155 17.6 No 4
MGST1-004 ENSP00000438308
ENST00000535309
P10620
Show all »
Show » Show » 87 10 No 1
MGST1-005 ENSP00000442557
ENST00000536371
F5H7F6
Show all »
Show » 77 8.9 No 1
MGST1-006 ENSP00000442970
ENST00000540126
F5H6X2
Show all »
Show » 80 9.2 No 1
MGST1-007 ENSP00000437988
ENST00000540056
F5H613
Show all »
Show » 46 5.3 No 1
MGST1-009 ENSP00000440443
ENST00000538885
F5GX73
Show all »
Show » 42 4.8 No 1
MGST1-013 ENSP00000442767
ENST00000543076
F5H760
Show all »
Show » 106 11.9 No 0
MGST1-201 ENSP00000010404
ENST00000010404
P10620
Show all »
Show » Show » 155 17.6 No 4
MGST1-202 ENSP00000379512
ENST00000396209
P10620
Show all »
Show » Show » 155 17.6 No 4