INS

GENERAL INFORMATION

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Gene name

INS

Gene description

Insulin

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (pancreas)
GTEx:Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein localization

Highly selective cytoplasmic expression in pancreatic islets.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 4 antibodies.
HPA004932 , CAB000048 , CAB012098 , CAB053843
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (pancreas)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (pancreas)

Organ

Expression



GENE INFORMATION

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Gene name

INS (HGNC Symbol)

Synonyms

IDDM1, IDDM2

Description

Insulin (HGNC Symbol)

Entrez gene summary

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

2159779 - 2161341

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000254647 (version 78.38)

Entrez gene

3630

UniProt

P01308 (UniProt - Evidence at protein level)

neXtProt

NX_P01308

Antibodypedia

INS antibodies


PROTEIN BROWSER

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ENST00000250971
 
ENST00000381330
 
ENST00000397262
 
ENST00000421783
 
ENST00000512523
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INS-001 ENSP00000370731
ENST00000381330
P01308
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Show » Show » 110 12 Yes 0
INS-002 ENSP00000250971
ENST00000250971
P01308
Show all »
Show » Show » 110 12 Yes 0
INS-003 ENSP00000380432
ENST00000397262
P01308
Show all »
Show » Show » 110 12 Yes 0
INS-005 ENSP00000408400
ENST00000421783
C9JNR5
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Show » Show » 92 10.6 Yes 0
INS-006 ENSP00000424008
ENST00000512523
A6XGL2
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Show » Show » 98 11 Yes 0