EFNA4

GENERAL INFORMATION

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Gene name

EFNA4

Gene description

Ephrin-A4

Protein class

Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Membrane,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB021350
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

EFNA4 (HGNC Symbol)

Synonyms

EPLG4, LERK4

Description

Ephrin-A4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

155063731 - 155069553

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000243364 (version 78.38)

Entrez gene

1945

UniProt

P52798 (UniProt - Evidence at protein level)

neXtProt

NX_P52798

Antibodypedia

EFNA4 antibodies


PROTEIN BROWSER

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ENST00000359751
 
ENST00000368409
 
ENST00000427683
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EFNA4-001 ENSP00000357394
ENST00000368409
P52798
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Show » Show » 201 22.4 Yes 1
EFNA4-002 ENSP00000352789
ENST00000359751
P52798
Show all »
Show » Show » 193 21.7 Yes 0
EFNA4-003 ENSP00000414378
ENST00000427683
P52798
Show all »
Show » Show » 207 22.6 Yes 0