ASPH - Gene info - The Human Protein Atlas

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ASPH

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	ASPH (HGNC Symbol)
Synonyms	BAH, CASQ2BP1, HAAH, JCTN
Description	Aspartate beta-hydroxylase (HGNC Symbol)
Entrez gene summary	This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
Chromosome	8
Cytoband	q12.3
Chromosome location (bp)	61500556 - 61714640
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198363 (version 78.38)
Entrez gene	444
UniProt	Q12797 (UniProt - Evidence at protein level)
neXtProt	NX_Q12797
Antibodypedia	ASPH antibodies

PROTEIN VIEW

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ASPH-001		ASPH-002		ASPH-003		ASPH-004		ASPH-005		ASPH-006		ASPH-008		ASPH-009		ASPH-011		ASPH-015		ASPH-016		ASPH-018		ASPH-021		ASPH-022		ASPH-023		ASPH-024		ASPH-028		ASPH-029		ASPH-032		ASPH-201		ASPH-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
ASPH-001	ENSP00000348841 ENST00000356457	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity]	313	34.6	No	1
ASPH-002	ENSP00000368767 ENST00000379454	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0007389 [pattern specification process] GO:0008285 [negative regulation of cell proliferation] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018193 [peptidyl-amino acid modification] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0031647 [regulation of protein stability] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0035108 [limb morphogenesis] GO:0042264 [peptidyl-aspartic acid hydroxylation] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060021 [palate development] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0060325 [face morphogenesis] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity] GO:1901879 [regulation of protein depolymerization]	758	85.9	No	1
ASPH-003	ENSP00000430245 ENST00000517903	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase B7ZM96 [Target identity:93%; Query identity:100%] ASPH protein {ECO:0000313\|EMBL:AAI44364.1}	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity]	298	33.7	No	1
ASPH-004	ENSP00000436188 ENST00000522603	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity]	210	23.8	No	1
ASPH-005	ENSP00000373856 ENST00000389204	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity]	225	25.6	No	1
ASPH-006	ENSP00000368762 ENST00000379449	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity]	203	22	No	1
ASPH-008	ENSP00000429286 ENST00000518068	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity]	270	29.8	No	1
ASPH-009	ENSP00000429160 ENST00000522835	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity]	256	28.9	No	1
ASPH-011	ENSP00000427823 ENST00000519234	E5RG56 Show all » « Hide E5RG56 [Target identity:100%; Query identity:100%] Aspartyl/asparaginyl beta-hydroxylase {ECO:0000313\|Ensembl:ENSP00000427823}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016020 [membrane]	327	36.3	No	1
ASPH-015	ENSP00000428060 ENST00000517661	G3XAN5 Show all » « Hide G3XAN5 [Target identity:100%; Query identity:100%] Aspartate beta-hydroxylase, isoform CRA_c {ECO:0000313\|EMBL:EAW86842.1}; Aspartyl/asparaginyl beta-hydroxylase {ECO:0000313\|Ensembl:ENSP00000428060}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016020 [membrane]	174	19.4	No	1
ASPH-016	ENSP00000427877 ENST00000518306	E5RG29 Show all » « Hide E5RG29 [Target identity:100%; Query identity:100%] Aspartyl/asparaginyl beta-hydroxylase {ECO:0000313\|Ensembl:ENSP00000427877}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016020 [membrane]	198	22.2	No	1
ASPH-018	ENSP00000429743 ENST00000517856	E5RHJ2 Show all » « Hide E5RHJ2 [Target identity:100%; Query identity:100%] Aspartyl/asparaginyl beta-hydroxylase {ECO:0000313\|Ensembl:ENSP00000429743}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016020 [membrane]	113	11.8	No	1
ASPH-021	ENSP00000483443 ENST00000519678		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016020 [membrane]	134	15.4	No	0
ASPH-022	ENSP00000479830 ENST00000519264		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		44	5.1	No	0
ASPH-023	ENSP00000430516 ENST00000522919	E5RJL3 Show all » « Hide E5RJL3 [Target identity:100%; Query identity:100%] Aspartyl/asparaginyl beta-hydroxylase {ECO:0000313\|Ensembl:ENSP00000430516}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016020 [membrane]	163	18.7	No	0
ASPH-024	ENSP00000429718 ENST00000522349	E5RHK2 Show all » « Hide E5RHK2 [Target identity:100%; Query identity:100%] Aspartyl/asparaginyl beta-hydroxylase {ECO:0000313\|Ensembl:ENSP00000429718}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016020 [membrane]	136	15.3	No	1
ASPH-028	ENSP00000479945 ENST00000524173		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0016020 [membrane]	196	22.7	No	0
ASPH-029	ENSP00000478706 ENST00000523927		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016020 [membrane]	186	21.2	No	0
ASPH-032	ENSP00000429954 ENST00000517847	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity]	299	33.8	No	1
ASPH-201	ENSP00000394013 ENST00000445642		Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016020 [membrane]	294	32.4	No	1
ASPH-202	ENSP00000437864 ENST00000541428	Q12797 Show all » « Hide Q12797 [Direct mapping] Aspartyl/asparaginyl beta-hydroxylase	Show » « Hide Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004597 [peptide-aspartate beta-dioxygenase activity] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005513 [detection of calcium ion] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0009055 [electron carrier activity] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014701 [junctional sarcoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018193 [peptidyl-amino acid modification] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity] GO:0032237 [activation of store-operated calcium channel activity] GO:0032541 [cortical endoplasmic reticulum] GO:0033017 [sarcoplasmic reticulum membrane] GO:0033018 [sarcoplasmic reticulum lumen] GO:0033198 [response to ATP] GO:0034704 [calcium channel complex] GO:0044325 [ion channel binding] GO:0045862 [positive regulation of proteolysis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity] GO:0070588 [calcium ion transmembrane transport] GO:0071277 [cellular response to calcium ion] GO:0090316 [positive regulation of intracellular protein transport] GO:0097202 [activation of cysteine-type endopeptidase activity]	729	83.3	No	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.