MBP

GENE INFORMATION

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Gene name

MBP

Synonyms

Description

Myelin basic protein (HGNC Symbol)

Entrez gene summary

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called ""Golli-MBP"") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

q23

Chromosome location (bp)

76978827 - 77133683

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197971 (version 78.38)

Entrez gene

4155

UniProt

P02686 (UniProt - Evidence at protein level)

neXtProt

NX_P02686

Antibodypedia

MBP antibodies
 

PROTEIN VIEW

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 « 
 
MBP-001
 
MBP-002
 
MBP-004
 
MBP-005
 
MBP-006
 
MBP-007
 
MBP-015
 
MBP-016
 
MBP-019
 
MBP-024
 
MBP-028
 
MBP-031
 
MBP-032
 
MBP-033
 
MBP-034
 
MBP-035
 
MBP-037
 
MBP-039
 
MBP-048
 
MBP-049
 
MBP-050
 
MBP-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MBP-001 ENSP00000352667
ENST00000359645
P02686
Show all »
Show » Show » 186 20.2 No 0
MBP-002 ENSP00000372025
ENST00000382582
P02686
Show all »
Show » Show » 197 21.5 No 0
MBP-004 ENSP00000380961
ENST00000397863
P02686
Show all »
Show » Show » 197 21.5 No 0
MBP-005 ENSP00000380958
ENST00000397860
P02686
Show all »
Show » Show » 197 21.5 No 0
MBP-006 ENSP00000380964
ENST00000397866
P02686
Show all »
Show » Show » 171 18.6 No 0
MBP-007 ENSP00000380963
ENST00000397865
P02686
Show all »
Show » Show » 160 17.3 No 0
MBP-015 ENSP00000437063
ENST00000498683
E9PNZ1
Show all »
Show » Show » 86 9.5 No 0
MBP-016 ENSP00000405882
ENST00000447114
C9J6H1
Show all »
Show » Show » 101 11.1 No 0
MBP-019 ENSP00000380973
ENST00000397875
A8MZH3
Show all »
Show » Show » 181 19.7 No 0
MBP-024 ENSP00000380967
ENST00000397869
H7BYR8
Show all »
Show » Show » 236 25.7 No 0
MBP-028 ENSP00000435641
ENST00000526111
E9PJ72
Show all »
Show » Show » 149 16.2 No 0
MBP-031 ENSP00000436830
ENST00000528160
E9PQE7
Show all »
Show » Show » 68 7.6 No 0
MBP-032 ENSP00000346545
ENST00000354542
F8WEU6
Show all »
Show » Show » 73 7.9 No 0
MBP-033 ENSP00000435243
ENST00000527041
E9PKX9
Show all »
Show » Show » 108 11.9 No 0
MBP-034 ENSP00000463164
ENST00000583798
J3QKN5
Show all »
Show » 41 4.5 No 0
MBP-035 ENSP00000462374
ENST00000581878
J3KS94
Show all »
Show » 159 17.4 No 0
MBP-037 ENSP00000463403
ENST00000578193
J3QL64
Show all »
Show » Show » 157 17.1 No 0
MBP-039 ENSP00000463137
ENST00000578873
J3QKL5
Show all »
Show » Show » 171 18.9 No 0
MBP-048 ENSP00000463780
ENST00000579129
J3QQK6
Show all »
Show » Show » 253 27.7 No 0
MBP-049 ENSP00000462223
ENST00000580402
P02686
Show all »
Show » Show » 304 33.1 No 0
MBP-050 ENSP00000462734
ENST00000585201
Show » Show » 180 19.4 No 0
MBP-201 ENSP00000348273
ENST00000355994
P02686
Show all »
Show » Show » 304 33.1 No 0